Epstein-Barr 病毒 60 周年研究里程碑。

IF 8 2区生物学 Q1 BIOLOGY

Science China Life Sciences Pub Date : 2024-11-04 DOI:10.1007/s11427-024-2766-0

Lan-Yi Zhong, Chu Xie, Le-Le Zhang, Yan-Lin Yang, Yuan-Tao Liu, Ge-Xin Zhao, Guo-Long Bu, Xian-Shu Tian, Zi-Ying Jiang, Bo-Yu Yuan, Peng-Lin Li, Pei-Huang Wu, Wei-Hua Jia, Christian Münz, Benjamin E Gewurz, Qian Zhong, Cong Sun, Mu-Sheng Zeng

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引用次数: 0

摘要

Epstein-Barr 病毒（EBV）是 1964 年发现的第一种人类肿瘤病毒，由于其独特的生物学特性和在人类疾病中的重要作用，它已成为病毒学、免疫学和肿瘤学的焦点。在我们纪念 EBV 发现 60 周年之际，正是反思我们对这种复杂病毒的认识所取得的重大进展的好时机。在这篇综述中，我们将重点介绍 EBV 研究的重要里程碑，包括其病毒结构和生命周期、与宿主免疫系统的相互作用、与 EBV 相关疾病的关联以及有针对性的干预策略。

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Research landmarks on the 60th anniversary of Epstein-Barr virus.

Epstein-Barr virus (EBV), the first human oncovirus discovered in 1964, has become a focal point in virology, immunology, and oncology because of its unique biological characteristics and significant role in human diseases. As we commemorate the 60th anniversary of EBV's discovery, it is an opportune moment to reflect on the major advancements in our understanding of this complex virus. In this review, we highlight key milestones in EBV research, including its virion structure and life cycle, interactions with the host immune system, association with EBV-associated diseases, and targeted intervention strategies.

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来源期刊

Science China Life Sciences BIOLOGY-

CiteScore

15.10

自引率

8.80%

发文量

2907

审稿时长

3.2 months

期刊介绍： Science China Life Sciences is a scholarly journal co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China, and it is published by Science China Press. The journal is dedicated to publishing high-quality, original research findings in both basic and applied life science research.