内皮细胞的机械感觉实体和功能。

IF 4.6 2区 生物学 Q2 CELL BIOLOGY
Frontiers in Cell and Developmental Biology Pub Date : 2024-10-23 eCollection Date: 2024-01-01 DOI:10.3389/fcell.2024.1446452
Claudia Tanja Mierke
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引用次数: 0

摘要

血液循环中的内皮细胞会受到血液动力的影响,如循环应变、静水压和由血液流体摩擦力引起的剪切应力。内皮细胞通过机械传感器感知机械力,从而引起生理反应,如血管宽度的改变。机械传感器包括离子通道、与质膜相连的结构、细胞骨架谱蛋白支架、机械感受器和连接蛋白。本综述将重点讨论内皮机械传感器及其如何改变内皮细胞的血管功能。本文简要介绍了疾病中内皮机械敏感性失调的知识现状。简要概述了内皮细胞和血管平滑肌细胞在机械感知方面的相互作用。最后,强调了克服现有局限性所必需的未来研究途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechanosensory entities and functionality of endothelial cells.

The endothelial cells of the blood circulation are exposed to hemodynamic forces, such as cyclic strain, hydrostatic forces, and shear stress caused by the blood fluid's frictional force. Endothelial cells perceive mechanical forces via mechanosensors and thus elicit physiological reactions such as alterations in vessel width. The mechanosensors considered comprise ion channels, structures linked to the plasma membrane, cytoskeletal spectrin scaffold, mechanoreceptors, and junctional proteins. This review focuses on endothelial mechanosensors and how they alter the vascular functions of endothelial cells. The current state of knowledge on the dysregulation of endothelial mechanosensitivity in disease is briefly presented. The interplay in mechanical perception between endothelial cells and vascular smooth muscle cells is briefly outlined. Finally, future research avenues are highlighted, which are necessary to overcome existing limitations.

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来源期刊
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
9.70
自引率
3.60%
发文量
2531
审稿时长
12 weeks
期刊介绍: Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.
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