Mihaela Rata, Matthew R Orton, Nina Tunariu, Andra Curcean, Julie Hughes, Erica Scurr, Matthew Blackledge, James d'Arcy, Yun Jiang, Vikas Gulani, Dow-Mu Koh
{"title":"用于前列腺癌患者转移性骨质 T1 和 T2 测量的定量 MR 指纹测量的重复性。","authors":"Mihaela Rata, Matthew R Orton, Nina Tunariu, Andra Curcean, Julie Hughes, Erica Scurr, Matthew Blackledge, James d'Arcy, Yun Jiang, Vikas Gulani, Dow-Mu Koh","doi":"10.1007/s00330-024-11162-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>MR fingerprinting (MRF) has the potential to quantify treatment response. This study evaluated the repeatability of MRF-derived T<sub>1</sub> and T<sub>2</sub> relaxation times in bone metastasis, bone, and muscle in patients with metastatic prostate cancer.</p><p><strong>Materials and methods: </strong>This prospective single-centre study included same-day repeated MRF acquisitions from 20 patients (August 2019-October 2020). Phantom and human data were acquired on a 1.5-T MR scanner using a research MRF sequence outputting T<sub>1</sub> and T<sub>2</sub> maps. Regions of interest (ROIs) across three tissue types (bone metastasis, bone, muscle) were drawn on two separate acquisitions. Repeatability of T<sub>1</sub> and T<sub>2</sub> was assessed using Bland-Altman plots, together with repeatability (r) and intraclass correlation (ICC) coefficients. Mean T<sub>1</sub> and T<sub>2</sub> were reported per tissue type.</p><p><strong>Results: </strong>Twenty patients with metastatic prostate cancer (mean age, 70 years ± 8 (standard deviation)) were evaluated and bone metastasis (n = 44), normal-appearing bone (n = 14), and muscle (n = 20) ROIs were delineated. Relative repeatability of T<sub>1</sub> measurements was 6.9% (bone metastasis), 32.6% (bone), 5.8% (muscle) and 21.8%, 32.2%, 16.1% for T<sub>2</sub> measurements. The ICC of T<sub>1</sub> was 0.97 (bone metastasis), 0.94 (bone), 0.96 (muscle); ICC of T<sub>2</sub> was 0.94 (bone metastasis), 0.94 (bone), 0.91 (muscle). T<sub>1</sub> values in bone metastasis were higher than in bone (p < 0.001). T<sub>2</sub> values showed no difference between bone metastasis and bone (p = 0.5), but could separate active versus treated metastasis (p < 0.001).</p><p><strong>Conclusion: </strong>MRF allows repeatable T<sub>1</sub> and T<sub>2</sub> measurements in bone metastasis, bone, and muscle in patients with primary prostate cancer. Such measurements may help quantify the treatment response of bone metastasis.</p><p><strong>Key points: </strong>Question MR fingerprinting has the potential to characterise bone metastasis and its response to treatment. Findings Repeatability of MRF-based T<sub>1</sub> measurements in bone metastasis and muscle was better than for T<sub>2</sub>. Clinical relevance MR fingerprinting allows repeatable T<sub>1</sub> and T<sub>2</sub> quantitative measurements in bone metastasis, bone, and muscle in patients with primary prostate cancer, which makes it potentially applicable for disease characterisation and assessment of treatment response.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Repeatability of quantitative MR fingerprinting for T<sub>1</sub> and T<sub>2</sub> measurements of metastatic bone in prostate cancer patients.\",\"authors\":\"Mihaela Rata, Matthew R Orton, Nina Tunariu, Andra Curcean, Julie Hughes, Erica Scurr, Matthew Blackledge, James d'Arcy, Yun Jiang, Vikas Gulani, Dow-Mu Koh\",\"doi\":\"10.1007/s00330-024-11162-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>MR fingerprinting (MRF) has the potential to quantify treatment response. This study evaluated the repeatability of MRF-derived T<sub>1</sub> and T<sub>2</sub> relaxation times in bone metastasis, bone, and muscle in patients with metastatic prostate cancer.</p><p><strong>Materials and methods: </strong>This prospective single-centre study included same-day repeated MRF acquisitions from 20 patients (August 2019-October 2020). Phantom and human data were acquired on a 1.5-T MR scanner using a research MRF sequence outputting T<sub>1</sub> and T<sub>2</sub> maps. Regions of interest (ROIs) across three tissue types (bone metastasis, bone, muscle) were drawn on two separate acquisitions. Repeatability of T<sub>1</sub> and T<sub>2</sub> was assessed using Bland-Altman plots, together with repeatability (r) and intraclass correlation (ICC) coefficients. Mean T<sub>1</sub> and T<sub>2</sub> were reported per tissue type.</p><p><strong>Results: </strong>Twenty patients with metastatic prostate cancer (mean age, 70 years ± 8 (standard deviation)) were evaluated and bone metastasis (n = 44), normal-appearing bone (n = 14), and muscle (n = 20) ROIs were delineated. Relative repeatability of T<sub>1</sub> measurements was 6.9% (bone metastasis), 32.6% (bone), 5.8% (muscle) and 21.8%, 32.2%, 16.1% for T<sub>2</sub> measurements. The ICC of T<sub>1</sub> was 0.97 (bone metastasis), 0.94 (bone), 0.96 (muscle); ICC of T<sub>2</sub> was 0.94 (bone metastasis), 0.94 (bone), 0.91 (muscle). T<sub>1</sub> values in bone metastasis were higher than in bone (p < 0.001). T<sub>2</sub> values showed no difference between bone metastasis and bone (p = 0.5), but could separate active versus treated metastasis (p < 0.001).</p><p><strong>Conclusion: </strong>MRF allows repeatable T<sub>1</sub> and T<sub>2</sub> measurements in bone metastasis, bone, and muscle in patients with primary prostate cancer. Such measurements may help quantify the treatment response of bone metastasis.</p><p><strong>Key points: </strong>Question MR fingerprinting has the potential to characterise bone metastasis and its response to treatment. Findings Repeatability of MRF-based T<sub>1</sub> measurements in bone metastasis and muscle was better than for T<sub>2</sub>. Clinical relevance MR fingerprinting allows repeatable T<sub>1</sub> and T<sub>2</sub> quantitative measurements in bone metastasis, bone, and muscle in patients with primary prostate cancer, which makes it potentially applicable for disease characterisation and assessment of treatment response.</p>\",\"PeriodicalId\":12076,\"journal\":{\"name\":\"European Radiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-11-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00330-024-11162-z\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00330-024-11162-z","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Repeatability of quantitative MR fingerprinting for T1 and T2 measurements of metastatic bone in prostate cancer patients.
Objectives: MR fingerprinting (MRF) has the potential to quantify treatment response. This study evaluated the repeatability of MRF-derived T1 and T2 relaxation times in bone metastasis, bone, and muscle in patients with metastatic prostate cancer.
Materials and methods: This prospective single-centre study included same-day repeated MRF acquisitions from 20 patients (August 2019-October 2020). Phantom and human data were acquired on a 1.5-T MR scanner using a research MRF sequence outputting T1 and T2 maps. Regions of interest (ROIs) across three tissue types (bone metastasis, bone, muscle) were drawn on two separate acquisitions. Repeatability of T1 and T2 was assessed using Bland-Altman plots, together with repeatability (r) and intraclass correlation (ICC) coefficients. Mean T1 and T2 were reported per tissue type.
Results: Twenty patients with metastatic prostate cancer (mean age, 70 years ± 8 (standard deviation)) were evaluated and bone metastasis (n = 44), normal-appearing bone (n = 14), and muscle (n = 20) ROIs were delineated. Relative repeatability of T1 measurements was 6.9% (bone metastasis), 32.6% (bone), 5.8% (muscle) and 21.8%, 32.2%, 16.1% for T2 measurements. The ICC of T1 was 0.97 (bone metastasis), 0.94 (bone), 0.96 (muscle); ICC of T2 was 0.94 (bone metastasis), 0.94 (bone), 0.91 (muscle). T1 values in bone metastasis were higher than in bone (p < 0.001). T2 values showed no difference between bone metastasis and bone (p = 0.5), but could separate active versus treated metastasis (p < 0.001).
Conclusion: MRF allows repeatable T1 and T2 measurements in bone metastasis, bone, and muscle in patients with primary prostate cancer. Such measurements may help quantify the treatment response of bone metastasis.
Key points: Question MR fingerprinting has the potential to characterise bone metastasis and its response to treatment. Findings Repeatability of MRF-based T1 measurements in bone metastasis and muscle was better than for T2. Clinical relevance MR fingerprinting allows repeatable T1 and T2 quantitative measurements in bone metastasis, bone, and muscle in patients with primary prostate cancer, which makes it potentially applicable for disease characterisation and assessment of treatment response.
期刊介绍：
European Radiology (ER) continuously updates scientific knowledge in radiology by publication of strong original articles and state-of-the-art reviews written by leading radiologists. A well balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes ER an indispensable source for current information in this field.
This is the Journal of the European Society of Radiology, and the official journal of a number of societies.
From 2004-2008 supplements to European Radiology were published under its companion, European Radiology Supplements, ISSN 1613-3749.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
