对转录因子的分子功能进行分类，而不仅仅是激活和抑制。

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2024-11-06 DOI:10.1101/gad.352340.124

Jinhong Dong, Michael J Guertin

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引用次数: 0

摘要

Notch 信号传导是一种高度保守的通路，通过动态的细胞相互作用激活分子级联，最终驱动基因表达的变化。Notch转录复合体（NTC）调控影响发育和稳态的基因。在本期《基因与发育》（Genes & Development）杂志上，Rogers及其同事（doi:10.1101/gad.352108.124）利用快速Notch激活系统与分子基因组剖析相结合，揭示了NTC调控暂停RNA聚合酶的释放以激活直接靶基因。他们还强调了 SWI/SNF 染色质重塑复合物在建立和维持染色质可及性以促进 NTC 靶基因激活方面的作用。

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Classifying the molecular functions of transcription factors beyond activation and repression.

Notch signaling is a highly conserved pathway activated by dynamic cellular interactions that initiates a molecular cascade that ultimately drives changes in gene expression. The Notch transcriptional complex (NTC) regulates genes that influence development and homeostasis. In this issue of Genes & Development, Rogers and colleagues (doi:10.1101/gad.352108.124) leverage a rapid Notch activation system combined with molecular genomic profiling to reveal that the NTC regulates the release of paused RNA polymerase to activate direct target genes. They also highlight the role of the SWI/SNF chromatin remodeling complex in establishing and maintaining chromatin accessibility to potentiate the activation of NTC target genes.

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).