{"title":"秋水仙碱导致血清 CA 72-4 异常升高的一个病例","authors":"Gangfeng Li, Tao Lu","doi":"10.7754/Clin.Lab.2024.240601","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>CA 72-4 is a tumor associated antigen which shows significantly increased serum levels in gastric cancer. It is the most commonly used serum tumor marker for diagnosing symptomatic gastric cancer and monitoring gastric cancer treatment.</p><p><strong>Methods: </strong>We report the case of a gout patient with abnormal elevation of serum CA 72-4 caused by taking colchicine.</p><p><strong>Results: </strong>The patient's painless gastroscopy and other examinations showed no obvious abnormalities, and no detection interference was detected. After discontinuing treatment with colchicine, CA 72-4 level of the patient returned to normal. Therefore, the abnormal increase of CA 72-4 is believed to be caused by colchicine.</p><p><strong>Conclusions: </strong>When gout patients receive colchicine treatment, it may lead to an abnormal increase in CA 72-4 results. Laboratory staff should consider the existence of such interference and promptly remind clinical doctors to avoid unnecessary examination and treatment of patients.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"70 11","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Case of Abnormal Elevation of Serum CA 72-4 Caused by Colchicine.\",\"authors\":\"Gangfeng Li, Tao Lu\",\"doi\":\"10.7754/Clin.Lab.2024.240601\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>CA 72-4 is a tumor associated antigen which shows significantly increased serum levels in gastric cancer. It is the most commonly used serum tumor marker for diagnosing symptomatic gastric cancer and monitoring gastric cancer treatment.</p><p><strong>Methods: </strong>We report the case of a gout patient with abnormal elevation of serum CA 72-4 caused by taking colchicine.</p><p><strong>Results: </strong>The patient's painless gastroscopy and other examinations showed no obvious abnormalities, and no detection interference was detected. After discontinuing treatment with colchicine, CA 72-4 level of the patient returned to normal. Therefore, the abnormal increase of CA 72-4 is believed to be caused by colchicine.</p><p><strong>Conclusions: </strong>When gout patients receive colchicine treatment, it may lead to an abnormal increase in CA 72-4 results. Laboratory staff should consider the existence of such interference and promptly remind clinical doctors to avoid unnecessary examination and treatment of patients.</p>\",\"PeriodicalId\":10384,\"journal\":{\"name\":\"Clinical laboratory\",\"volume\":\"70 11\",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical laboratory\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.7754/Clin.Lab.2024.240601\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2024.240601","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景：CA 72-4是一种肿瘤相关抗原，在胃癌患者中血清水平明显升高。它是诊断无症状胃癌和监测胃癌治疗最常用的血清肿瘤标志物：我们报告了一例因服用秋水仙碱导致血清 CA 72-4 异常升高的痛风患者：结果：患者的无痛胃镜及其他检查未见明显异常，也未发现检测干扰。停用秋水仙碱治疗后，患者的 CA 72-4 水平恢复正常。因此，CA 72-4 的异常升高被认为是由秋水仙碱引起的：结论：痛风患者接受秋水仙碱治疗时，可能会导致CA 72-4结果异常升高。结论：痛风患者接受秋水仙碱治疗时，可能会导致CA 72-4结果异常升高，实验室工作人员应考虑到这种干扰的存在，并及时提醒临床医生避免对患者进行不必要的检查和治疗。
A Case of Abnormal Elevation of Serum CA 72-4 Caused by Colchicine.
Background: CA 72-4 is a tumor associated antigen which shows significantly increased serum levels in gastric cancer. It is the most commonly used serum tumor marker for diagnosing symptomatic gastric cancer and monitoring gastric cancer treatment.
Methods: We report the case of a gout patient with abnormal elevation of serum CA 72-4 caused by taking colchicine.
Results: The patient's painless gastroscopy and other examinations showed no obvious abnormalities, and no detection interference was detected. After discontinuing treatment with colchicine, CA 72-4 level of the patient returned to normal. Therefore, the abnormal increase of CA 72-4 is believed to be caused by colchicine.
Conclusions: When gout patients receive colchicine treatment, it may lead to an abnormal increase in CA 72-4 results. Laboratory staff should consider the existence of such interference and promptly remind clinical doctors to avoid unnecessary examination and treatment of patients.
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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