达拉斯体外循环死亡后捐献移植峰会:通过流程改进、更广泛的利用和创新,扩大体外循环死亡后捐献程序。

IF 6.1 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Hepatobiliary surgery and nutrition Pub Date : 2024-10-01 Epub Date: 2024-04-25 DOI:10.21037/hbsn-23-503
Michele Finotti, Anji Wall, Anthony D'Alessandro, Gary Schwartz, Chris Sonnenday, David Goldberg, Ashish Shah, Peter Friend, Jeff P Orlowski, Greg McKenna, Steve Newton, Brad Adams, William C Chapman, Amit Mathur, Marwan Abouljoud, Tim Pruett, Amelia Hessheimer, James F Trotter, Sumeet K Asrani, Giuliano Testa
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引用次数: 0

摘要

尽管在过去十年中,循环死亡后捐献(DCD)器官的利用率大幅提高,但在美国采购和移植的DCD器官数量仍远低于其潜力。由于充分利用 DCD 器官是目前解决移植供需长期不匹配的最可行办法,因此仍有扩大的空间。我们召开了一次多学科移植峰会,与来自世界各地对 DCD 捐赠和移植有临床和学术兴趣的教员,包括腹部和心胸外科医生、器官采购组织主任、肝病专家和肠胃病专家,共同探讨 DCD 的各个方面。会议的重点是确定 DCD 器官利用的障碍以及克服这些障碍的策略。我们将使用 DCD 的障碍分为三大类:(I)政策和流程差异;(II)后勤和运输挑战;以及(III)与 DCD 结果相关的较高风险认知。针对每个障碍,我们提出了各种解决方案,概述了美国 DCD 捐赠的现状,并就如何增加 DCD 的使用提出了建议。我们特别关注了原位机器灌注、常温区域灌注以及在不对受体结果产生负面影响的情况下扩大 DCD 使用的其他机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Dallas Donation after Circulatory Death Transplantation Summit: expanding donation after circulatory death procedures through process improvement, broader utilization, and innovation.

Despite a significant increase in utilization over the past decade, the number of donation after circulatory death (DCD) organs that are procured and transplanted in the United States (US) remains well below its potential. There is still room for expansion, as utilizing DCD organs to the fullest extent is currently the most viable solution to the persistent mismatch between supply and demand in transplantation. We convened a multidisciplinary transplantation summit to examine various aspects of DCD, with faculty members from around the world with clinical and academic interest in DCD donation and transplantation, including abdominal and cardiothoracic surgeons, organ procurement organization directors, hepatologists, and gastroenterologists. The conference focused on identifying barriers to DCD organ utilization and strategies to overcome these barriers. We divide the barriers to DCD utilization into three mains categories: (I) policy and process variation; (II) logistical and transportation challenges; and (III) higher risk perceptions related to DCD outcomes. For each barrier, we proposed a variety of solutions, providing an overview of the status of DCD donation in the US and suggestions on how to increase the use of DCD. There is a specific focus on ex situ machine perfusion, normothermic regional perfusion, and other opportunities to expand DCD utilization without negatively impacting recipient outcomes.

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来源期刊
自引率
10.00%
发文量
392
期刊介绍: Hepatobiliary Surgery and Nutrition (HBSN) is a bi-monthly, open-access, peer-reviewed journal (Print ISSN: 2304-3881; Online ISSN: 2304-389X) since December 2012. The journal focuses on hepatopancreatobiliary disease and nutrition, aiming to present new findings and deliver up-to-date, practical information on diagnosis, prevention, and clinical investigations. Areas of interest cover surgical techniques, clinical and basic research, transplantation, therapies, NASH, NAFLD, targeted drugs, gut microbiota, metabolism, cancer immunity, genomics, and nutrition and dietetics. HBSN serves as a valuable resource for professionals seeking insights into diverse aspects of hepatobiliary surgery and nutrition.
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