系统免疫炎症指数作为经皮冠状动脉介入术后对比度诱发急性肾损伤风险的新型预测生物标志物：队列研究的 Meta 分析。

IF 2.8 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Current vascular pharmacology Pub Date : 2024-11-05 DOI:10.2174/0115701611328810241028112700

Yongqiang Zhang, Yong Xie, Chunyu Zhang, Jianglin Wang, Bin Liao, Jian Feng

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引用次数: 0

摘要

背景：造影剂诱导的急性肾损伤（CI-AKI）经常作为PCI术后并发症出现，因此识别高危患者具有挑战性。虽然全身免疫炎症指数（SII）可能有助于预测 CI-AKI，但目前的证据仍然不足：我们使用 PubMed、Web of Science、Embase 和 Cochrane Library 进行了系统性文献检索，截止日期为 2024 年 3 月 20 日。我们纳入了研究 SII 对 CI-AKI 风险预测价值的观察性研究：该荟萃分析包括 8 项研究，共有 6301 名参与者。结果显示，汇总的敏感性和特异性分别为 0.73（95% CI 0.69-0.76）和 0.68（95% CI 0.57-0.77）。sROC曲线分析显示AUC为0.74（95% CI 0.70-0.78）。发表偏倚风险较低（P = 0.18）：本研究结果表明，SII具有相对较高的灵敏度，可作为预测接受PCI治疗者CI-AKI风险的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Systemic Immune Inflammation Index as a Novel Predictive Biomarker for Contrast-Induced Acute Kidney Injury Risk Following Percutaneous Coronary Intervention: A Meta-Analysis of Cohort Studies.

Background: Contrast-induced Acute Kidney Injury (CI-AKI) frequently occurs as a complication following PCI, making the identification of high-risk patients challenging. While the systemic immune inflammation index (SII) might aid in predicting CI-AKI, the current evidence remains insufficient.

Methods: We conducted a systematic literature search using PubMed, Web of Science, Embase, and the Cochrane Library, with a cut-off date of 3/20/2024. We included observational studies that examined the predictive value of SII for the risk of CI-AKI.

Results: This meta-analysis encompassed 8 studies with a combined total of 6301 participants. Results showed pooled sensitivity and specificity of 0.73 (95% CI 0.69-0.76) and 0.68 (95% CI 0.57- 0.77), respectively. The sROC curve analysis indicated an AUC of 0.74 (95% CI 0.70-0.78). The risk of publication bias was low (p = 0.18).

Conclusion: The results of this study suggest that SII has a relatively high sensitivity and could function as a biomarker for the prediction of CI-AKI risk in people receiving PCI treatment.

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来源期刊

Current vascular pharmacology 医学-外周血管病

CiteScore

9.20

自引率

4.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Vascular Pharmacology publishes clinical and research-based reviews/mini-reviews, original research articles, letters, debates, drug clinical trial studies and guest edited issues to update all those concerned with the treatment of vascular disease, bridging the gap between clinical practice and ongoing research. Vascular disease is the commonest cause of death in Westernized countries and its incidence is on the increase in developing countries. It follows that considerable research is directed at establishing effective treatment for acute vascular events. Long-term treatment has also received considerable attention (e.g. for symptomatic relief). Furthermore, effective prevention, whether primary or secondary, is backed by the findings of several landmark trials. Vascular disease is a complex field with primary care physicians and nurse practitioners as well as several specialties involved. The latter include cardiology, vascular and cardio thoracic surgery, general medicine, radiology, clinical pharmacology and neurology (stroke units).