膳食炎症指数可预测曾患妊娠糖尿病妇女的糖尿病前期症状。

IF 3.4 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Yanhong Xu, Zhiying Yao, Jiayi Lin, Nan Wei, Ling Yao
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引用次数: 0

摘要

导言:妊娠糖尿病(GDM)与罹患 2 型糖尿病(T2DM)的风险增加有关。饮食中的炎症潜能对 GDM 的发展至关重要。本研究比较了有 GDM 病史和无 GDM 病史女性的饮食炎症指数(DII),并构建了糖尿病前期风险预测模型:方法:使用 DII 分析 NHANES 周期(2011-2014 年)的横断面数据。独立t检验、卡方检验和曼-惠特尼U检验检验了DII得分与GDM病史的关系。多变量逻辑回归评估了有 GDM 史的女性中 DII 与糖尿病前期的关系。限制立方样条曲线(RCS)和LASSO回归对非线性关系进行建模,并预测糖尿病前期风险:共纳入 971 名女性参与者。有 GDM 史的女性 DII 得分较低(1.62 (0.58, 2.93) vs. 2.05 (0.91, 2.93))。患有 GDM 的女性较高的 DII 分数与糖尿病前期有关,在调整了混杂因素后仍具有显著性。RCS 分析没有发现非线性相关性(非线性 p = 0.617)。有 GDM 史的糖尿病前期模型具有很强的预测能力(AUC = 88.6%,95% CI:79.9-97.4%):结论:有 GDM 史的女性的 DII 水平较低,这可能反映了饮食和健康意识的提高。较高的 DII 分数与该群体糖尿病前期风险的增加相关,强调了饮食在糖尿病风险中的作用。还需要进一步的研究来证实这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dietary inflammatory index as a predictor of prediabetes in women with previous gestational diabetes mellitus.

Introduction: Gestational diabetes mellitus (GDM) is associated with an increased risk of developing type 2 diabetes mellitus (T2DM). The inflammatory potential of diet is crucial in GDM development. This study compares dietary inflammatory indices (DII) in females with and without a history of GDM and constructs a predictive model for prediabetes risk.

Methods: Cross-sectional data from NHANES cycles (2011-2014) were analyzed using the DII. Independent t tests, chi-square test, and Mann-Whitney U test examined DII scores in relation to GDM history. Multivariate logistic regression assessed DII's association with prediabetes in females with GDM history. Restricted cubic spline (RCS) and LASSO regression modeled non-linear relationships and predicted prediabetes risk.

Results: 971 female participants were included. Those with GDM history had lower DII scores (1.62 (0.58, 2.93) vs. 2.05 (0.91, 2.93)). Higher DII scores in females with GDM were linked to prediabetes, remaining significant after adjusting for confounders. RCS analysis found no non-linear correlation (non-linear p = 0.617). The prediabetes model for GDM history had strong predictive performance (AUC = 88.6%, 95% CI: 79.9-97.4%).

Conclusion: Females with GDM history show lower DII levels, potentially reflecting improved diet and health awareness. Higher DII scores correlate with increased prediabetes risk in this group, emphasizing diet's role in diabetes risk. Further studies are needed to confirm these findings.

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来源期刊
Diabetology & Metabolic Syndrome
Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-
CiteScore
6.20
自引率
0.00%
发文量
170
审稿时长
7.5 months
期刊介绍: Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.
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