{"title":"用于生产 1,3-丙二醇的工程微生物","authors":"Ruotong Du, Hongzhi Ling, Keke Cheng","doi":"10.1002/bbb.2672","DOIUrl":null,"url":null,"abstract":"<p>1,3-Propanediol (1,3-PDO) has multiple practical applications, for example as an antifreeze and protective agent and as a monomer of partially renewable polyester and polyurethane. The main method for 1,3-PDO production is currently microbial fermentation. Bio-based 1,3-PDO can use renewable materials as substrates, and the process is mild and environmentally friendly.</p><p>Genetic engineering of microorganisms is crucial to achieve substrate diversity, reduce byproducts to decrease production costs, and facilitate the downstream processing of 1,3-PDO. This paper reviews the metabolic engineering of 1,3-PDO in natural and non-natural producers. In particular, it discusses current progress using non-natural synthetic pathways to obtain 1,3-propanediol.</p><p>Finally, strategies such as integrated production with other high-value-added products are proposed for successful commercialization.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"18 6","pages":"2116-2131"},"PeriodicalIF":3.2000,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Engineering microbes for 1,3-propanediol production\",\"authors\":\"Ruotong Du, Hongzhi Ling, Keke Cheng\",\"doi\":\"10.1002/bbb.2672\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>1,3-Propanediol (1,3-PDO) has multiple practical applications, for example as an antifreeze and protective agent and as a monomer of partially renewable polyester and polyurethane. The main method for 1,3-PDO production is currently microbial fermentation. Bio-based 1,3-PDO can use renewable materials as substrates, and the process is mild and environmentally friendly.</p><p>Genetic engineering of microorganisms is crucial to achieve substrate diversity, reduce byproducts to decrease production costs, and facilitate the downstream processing of 1,3-PDO. This paper reviews the metabolic engineering of 1,3-PDO in natural and non-natural producers. In particular, it discusses current progress using non-natural synthetic pathways to obtain 1,3-propanediol.</p><p>Finally, strategies such as integrated production with other high-value-added products are proposed for successful commercialization.</p>\",\"PeriodicalId\":55380,\"journal\":{\"name\":\"Biofuels Bioproducts & Biorefining-Biofpr\",\"volume\":\"18 6\",\"pages\":\"2116-2131\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-08-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biofuels Bioproducts & Biorefining-Biofpr\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/bbb.2672\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biofuels Bioproducts & Biorefining-Biofpr","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bbb.2672","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Engineering microbes for 1,3-propanediol production
1,3-Propanediol (1,3-PDO) has multiple practical applications, for example as an antifreeze and protective agent and as a monomer of partially renewable polyester and polyurethane. The main method for 1,3-PDO production is currently microbial fermentation. Bio-based 1,3-PDO can use renewable materials as substrates, and the process is mild and environmentally friendly.
Genetic engineering of microorganisms is crucial to achieve substrate diversity, reduce byproducts to decrease production costs, and facilitate the downstream processing of 1,3-PDO. This paper reviews the metabolic engineering of 1,3-PDO in natural and non-natural producers. In particular, it discusses current progress using non-natural synthetic pathways to obtain 1,3-propanediol.
Finally, strategies such as integrated production with other high-value-added products are proposed for successful commercialization.
期刊介绍：
Biofuels, Bioproducts and Biorefining is a vital source of information on sustainable products, fuels and energy. Examining the spectrum of international scientific research and industrial development along the entire supply chain, The journal publishes a balanced mixture of peer-reviewed critical reviews, commentary, business news highlights, policy updates and patent intelligence. Biofuels, Bioproducts and Biorefining is dedicated to fostering growth in the biorenewables sector and serving its growing interdisciplinary community by providing a unique, systems-based insight into technologies in these fields as well as their industrial development.
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