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引用次数: 0
摘要
花生四烯酸（AA）广泛分布于许多器官，可通过多种方式代谢成小脂质分子：二十烷酸，发挥生理和/或病理生理作用。其中，由细胞色素 P450（CYP）酶产生的环氧二十碳三烯酸（EET）和羟基二十碳四烯酸（HETE）备受关注。AA 代谢物在细胞增殖、分化和凋亡等过程中发挥重要作用，还参与器官和组织的发育以及各种疾病的发病过程；特别是，在 CYP 参与下形成的 AA 代谢物参与了与心血管系统功能相关的正常和病理过程。本综述侧重于 CYP 生成的 AA 代谢物的形成及其对心血管的影响，并总结了有关依赖 CYP 的 AA 代谢途径的生理和病理生理学意义及其与心血管系统在健康和疾病中的相关性的现有文献数据。
The Role of Arachidonic Acid Metabolizing Cytochromes P450 in the Control of Cardiovascular Functions
Arachidonic acid (AA) is widely distributed in many organs and can be metabolized in several ways into small lipid molecules: eicosanoides that perform a physiological and/or pathophysiological role. Among them, epoxyeicosatrienoic acids (EET) and hydroxyeicosatetraenoic acids (HETE), which are produced by cytochrome P450 (CYP) enzymes, have attracted much attention. AA metabolites play an important role in such cellular processes as proliferation, differentiation, and apoptosis and are also involved in the development of organs and tissues as well as in the pathogenetic processes underlying the development of various diseases; in particular, AA metabolites formed with the participation of CYP are involved in normal and pathological processes associated with the functioning of the cardiovascular system. This review focuses on the formation and cardiovascular effects of CYP-generated AA metabolites and summarizes current literature data on the physiological and pathophysiological significance of the CYP-dependent AA metabolic pathway and its relevance to the cardiovascular system in both health and disease.
期刊介绍：
Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.
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