Glycosmis craibii var. glabra 中的氮氧化物抑制成分

IF 4 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
{"title":"Glycosmis craibii var. glabra 中的氮氧化物抑制成分","authors":"","doi":"10.1016/S1875-5364(24)60632-1","DOIUrl":null,"url":null,"abstract":"<div><div>Six novel compounds, comprising three quinolones (<strong>1a</strong>, <strong>1b</strong>, and <strong>2</strong>) and three flavanones (<strong>3</strong>–<strong>5</strong>), along with seven known analogs (<strong>6</strong>–<strong>13</strong>), were isolated from the 95% EtOH extract of the stems and leaves of <em>Glycosmis craibii</em> var. <em>glabra</em>. The structures of the new compounds were elucidated using HR-ESI-MS, UV, and 1D and 2D nuclear magnetic resonance (NMR) data analysis. The absolute configurations were determined through Mosher ester and electronic circular dichroism (ECD) spectral analysis. Compounds <strong>2, 6, 9</strong>, and <strong>10</strong> demonstrated inhibition of nitric oxide (NO) production stimulated by lipopolysaccharide in BV-2 microglial cells, with IC<sub>50</sub> values ranging from 13.5 to 20.1 μmol·L<sup>−1</sup>, comparable to the positive control, dexamethasone.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"NO inhibitory constituents from Glycosmis craibii var. glabra\",\"authors\":\"\",\"doi\":\"10.1016/S1875-5364(24)60632-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Six novel compounds, comprising three quinolones (<strong>1a</strong>, <strong>1b</strong>, and <strong>2</strong>) and three flavanones (<strong>3</strong>–<strong>5</strong>), along with seven known analogs (<strong>6</strong>–<strong>13</strong>), were isolated from the 95% EtOH extract of the stems and leaves of <em>Glycosmis craibii</em> var. <em>glabra</em>. The structures of the new compounds were elucidated using HR-ESI-MS, UV, and 1D and 2D nuclear magnetic resonance (NMR) data analysis. The absolute configurations were determined through Mosher ester and electronic circular dichroism (ECD) spectral analysis. Compounds <strong>2, 6, 9</strong>, and <strong>10</strong> demonstrated inhibition of nitric oxide (NO) production stimulated by lipopolysaccharide in BV-2 microglial cells, with IC<sub>50</sub> values ranging from 13.5 to 20.1 μmol·L<sup>−1</sup>, comparable to the positive control, dexamethasone.</div></div>\",\"PeriodicalId\":10002,\"journal\":{\"name\":\"Chinese Journal of Natural Medicines\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Journal of Natural Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1875536424606321\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Natural Medicines","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1875536424606321","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0

摘要

从 Glycosmis craibii var. glabra 的茎和叶的 95% EtOH 提取物中分离出六种新化合物,包括三种喹诺酮类(1a、1b 和 2)和三种黄酮类(3-5),以及七种已知类似物(6-13)。利用 HR-ESI-MS、紫外光谱以及一维和二维核磁共振(NMR)数据分析阐明了这些新化合物的结构。通过莫舍酯和电子圆二色性(ECD)光谱分析确定了绝对构型。化合物 2、6、9 和 10 能抑制 BV-2 微神经胶质细胞在脂多糖刺激下产生一氧化氮,其 IC50 值为 13.5 至 20.1 μmol-L-1,与阳性对照地塞米松相当。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
NO inhibitory constituents from Glycosmis craibii var. glabra
Six novel compounds, comprising three quinolones (1a, 1b, and 2) and three flavanones (35), along with seven known analogs (613), were isolated from the 95% EtOH extract of the stems and leaves of Glycosmis craibii var. glabra. The structures of the new compounds were elucidated using HR-ESI-MS, UV, and 1D and 2D nuclear magnetic resonance (NMR) data analysis. The absolute configurations were determined through Mosher ester and electronic circular dichroism (ECD) spectral analysis. Compounds 2, 6, 9, and 10 demonstrated inhibition of nitric oxide (NO) production stimulated by lipopolysaccharide in BV-2 microglial cells, with IC50 values ranging from 13.5 to 20.1 μmol·L−1, comparable to the positive control, dexamethasone.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Chinese Journal of Natural Medicines
Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY
CiteScore
7.50
自引率
4.30%
发文量
2235
期刊介绍: The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信