铜(II)催化伯胺在三氯乙腈帮助下脱水成腈纶

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2024-10-15 DOI:10.1080/00397911.2024.2415442

Xiaoyun Ma , Xiaoyan Wan , Jun Zhao

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引用次数: 0

摘要

介绍了一种使用三氯乙腈和催化量的乙酸铜从伯胺制备腈的方法。利用这种方法，包括芳香族酰胺、芳香族杂环酰胺和脂肪族酰胺在内的酰胺被转化为相应的腈，产率为中等到良好。三氯乙腈与酰胺在醋酸铜存在下反应生成三氯乙酰胺，该反应已被分离和确认。

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Copper(II)-catalyzed dehydration of primary amides to nitriles with the aid of trichloroacetonitrile

A method for the preparation of nitriles from primary amides using trichloroacetonitrile and a catalytic amount of cupric acetate is described. Using this method, amides including aromatic amides, aromatic heterocyclic amides and aliphatic amides were converted into the corresponding nitriles in moderate to good yields. Trichloroacetonitrile reacted with amide in the presence of cupric acetate to form trichloroacetamide, which has been isolated and confirmed.

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.