{"title":"可可脂和芝麻油油凝胶作为新型营养保健品输送系统","authors":"Dheerendra Kumar Suman, Kunal Pal, Biswaranjan Mohanty* and Rajeswara Reddy Erva*, ","doi":"10.1021/acs.cgd.4c0120510.1021/acs.cgd.4c01205","DOIUrl":null,"url":null,"abstract":"<p >Novel oleogel formulations for nutraceutical administration using sesame oil (SO) and kokum butter (KB) were presented. KB aligned and enhanced formulation by entrapping the SO. SO–KB gelation required 20% w/w. KB (22.5–35% w/w) was utilized to make oleogel formulations. Oleogels, according to various microscopes, showed fat molecules aggregating in the oil matrix. Fourier transform infrared (FTIR) spectroscopy showed no molecular interactions between the oil and butter molecules. Mechanical studies showed that oleogel formulations are viscoelastic and strengthen with increasing KB. The formulation with more KB exhibited the highest crystallization rate and nucleation process. X-ray diffraction (XRD) evaluation showed that the formulation with the highest KB concentration had the largest crystalline particle size. A drug release study explored how KB affected curcumin (CRU) release at pH 6.8 and 1.2. Finally, these oleogels showed promising nutraceutical delivery functions.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"24 21","pages":"9182–9197 9182–9197"},"PeriodicalIF":3.2000,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Kokum Butter and Sesame Oil-Based Oleogels as Novel Nutraceutical Delivery Systems\",\"authors\":\"Dheerendra Kumar Suman, Kunal Pal, Biswaranjan Mohanty* and Rajeswara Reddy Erva*, \",\"doi\":\"10.1021/acs.cgd.4c0120510.1021/acs.cgd.4c01205\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Novel oleogel formulations for nutraceutical administration using sesame oil (SO) and kokum butter (KB) were presented. KB aligned and enhanced formulation by entrapping the SO. SO–KB gelation required 20% w/w. KB (22.5–35% w/w) was utilized to make oleogel formulations. Oleogels, according to various microscopes, showed fat molecules aggregating in the oil matrix. Fourier transform infrared (FTIR) spectroscopy showed no molecular interactions between the oil and butter molecules. Mechanical studies showed that oleogel formulations are viscoelastic and strengthen with increasing KB. The formulation with more KB exhibited the highest crystallization rate and nucleation process. X-ray diffraction (XRD) evaluation showed that the formulation with the highest KB concentration had the largest crystalline particle size. A drug release study explored how KB affected curcumin (CRU) release at pH 6.8 and 1.2. Finally, these oleogels showed promising nutraceutical delivery functions.</p>\",\"PeriodicalId\":34,\"journal\":{\"name\":\"Crystal Growth & Design\",\"volume\":\"24 21\",\"pages\":\"9182–9197 9182–9197\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Crystal Growth & Design\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.cgd.4c01205\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Crystal Growth & Design","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.cgd.4c01205","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Kokum Butter and Sesame Oil-Based Oleogels as Novel Nutraceutical Delivery Systems
Novel oleogel formulations for nutraceutical administration using sesame oil (SO) and kokum butter (KB) were presented. KB aligned and enhanced formulation by entrapping the SO. SO–KB gelation required 20% w/w. KB (22.5–35% w/w) was utilized to make oleogel formulations. Oleogels, according to various microscopes, showed fat molecules aggregating in the oil matrix. Fourier transform infrared (FTIR) spectroscopy showed no molecular interactions between the oil and butter molecules. Mechanical studies showed that oleogel formulations are viscoelastic and strengthen with increasing KB. The formulation with more KB exhibited the highest crystallization rate and nucleation process. X-ray diffraction (XRD) evaluation showed that the formulation with the highest KB concentration had the largest crystalline particle size. A drug release study explored how KB affected curcumin (CRU) release at pH 6.8 and 1.2. Finally, these oleogels showed promising nutraceutical delivery functions.
期刊介绍：
The aim of Crystal Growth & Design is to stimulate crossfertilization of knowledge among scientists and engineers working in the fields of crystal growth, crystal engineering, and the industrial application of crystalline materials.
Crystal Growth & Design publishes theoretical and experimental studies of the physical, chemical, and biological phenomena and processes related to the design, growth, and application of crystalline materials. Synergistic approaches originating from different disciplines and technologies and integrating the fields of crystal growth, crystal engineering, intermolecular interactions, and industrial application are encouraged.
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