单中心卡斯特曼病:关于纺锤形细胞增生和侵袭性局部疾病的最新进展和新见解》(Unicentric Castleman Disease: Updates and Novel Insights into Spindle Cell Proliferations and Aggressive Forms of a Localized Disease)。
Fnu Alnoor, Alexandra Rangel, Matthew Luo, Oscar Silva, Karen M Chisholm, Dennis O'Malley, Roger Warnke, Jyoti Kumar, Robert S Ohgami
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Unicentric Castleman Disease: Updates and Novel Insights Into Spindle Cell Proliferations and Aggressive Forms of a Localized Disease.
Castleman Disease (CD) is a rare lymphoproliferative disorder that can be separated into two primary forms: Unicentric Castleman disease (UCD) and multicentric Castleman disease (MCD). UCD is localized, while MCD is systemic. Though UCD generally has a favorable prognosis following surgical resection, more aggressive forms of this disease have been identified, including cases associated with dendritic and spindle cell proliferation. Genetic analysis has deepened our understanding of UCD. Despite advancements in better understanding the pathophysiology of UCD, challenges persist in the diagnosis, management, and treatment due to its rarity and heterogeneity. Here, we review current knowledge on UCD, highlighting the epidemiology, clinical presentation, diagnostic criteria, and treatment options while emphasizing the need for further research and innovation in therapeutic strategies.