{"title":"lncRNA FEZF1-AS1 通过 P53 信号通路在结直肠癌进展中的作用","authors":"Minglu Ding, Wanyao Wang, Keyuan Huo, Yidan Song, Xiaojie Chen, Zihan Xiang, Peijian Chen, Lantao Liu","doi":"10.1089/dna.2024.0184","DOIUrl":null,"url":null,"abstract":"<p><p>Long noncoding RNAs (lncRNAs) have emerged as critical regulators in the development of colorectal cancer (CRC). Previous studies indicate that lncRNA <i>FEZF1-AS1</i> is highly expressed in CRC, but its role in modulating CRC via the <i>P53</i> signaling pathway remains unclear. In this study, we found that <i>FEZF1-AS1</i> promotes the growth of the CRC cell line (HCT116) and drives epithelial-mesenchymal transition (EMT) through the <i>P53</i> signaling pathway. Our data showed that <i>FEZF1-AS1</i> expression is significantly upregulated in HCT116, and elevated levels of <i>FEZF1-AS1</i> are associated with poor prognosis in patients with CRC. In addition, the knockdown of <i>FEZF1-AS1</i> markedly inhibited the proliferation of HCT116 by inducing cell cycle arrest. Knockdown of <i>FEZF1-AS1</i> depletion also led to apoptosis in CRC cells by suppressing the <i>P53</i> signaling pathway and EMT, thereby reducing their viability, proliferation, migration, and invasion. In summary, this study confirmed that <i>FEZF1-AS1</i> regulates the growth of junction HCT116 through <i>P53</i> signaling pathway and inhibiting EMT, providing new insights for the potential therapeutic strategies against CRC.</p>","PeriodicalId":93981,"journal":{"name":"DNA and cell biology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Role of lncRNA <i>FEZF1-AS1</i> in Colorectal Cancer Progression Via the <i>P53</i> Signaling Pathway.\",\"authors\":\"Minglu Ding, Wanyao Wang, Keyuan Huo, Yidan Song, Xiaojie Chen, Zihan Xiang, Peijian Chen, Lantao Liu\",\"doi\":\"10.1089/dna.2024.0184\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Long noncoding RNAs (lncRNAs) have emerged as critical regulators in the development of colorectal cancer (CRC). Previous studies indicate that lncRNA <i>FEZF1-AS1</i> is highly expressed in CRC, but its role in modulating CRC via the <i>P53</i> signaling pathway remains unclear. In this study, we found that <i>FEZF1-AS1</i> promotes the growth of the CRC cell line (HCT116) and drives epithelial-mesenchymal transition (EMT) through the <i>P53</i> signaling pathway. Our data showed that <i>FEZF1-AS1</i> expression is significantly upregulated in HCT116, and elevated levels of <i>FEZF1-AS1</i> are associated with poor prognosis in patients with CRC. In addition, the knockdown of <i>FEZF1-AS1</i> markedly inhibited the proliferation of HCT116 by inducing cell cycle arrest. Knockdown of <i>FEZF1-AS1</i> depletion also led to apoptosis in CRC cells by suppressing the <i>P53</i> signaling pathway and EMT, thereby reducing their viability, proliferation, migration, and invasion. In summary, this study confirmed that <i>FEZF1-AS1</i> regulates the growth of junction HCT116 through <i>P53</i> signaling pathway and inhibiting EMT, providing new insights for the potential therapeutic strategies against CRC.</p>\",\"PeriodicalId\":93981,\"journal\":{\"name\":\"DNA and cell biology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"DNA and cell biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1089/dna.2024.0184\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"DNA and cell biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1089/dna.2024.0184","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Role of lncRNA FEZF1-AS1 in Colorectal Cancer Progression Via the P53 Signaling Pathway.
Long noncoding RNAs (lncRNAs) have emerged as critical regulators in the development of colorectal cancer (CRC). Previous studies indicate that lncRNA FEZF1-AS1 is highly expressed in CRC, but its role in modulating CRC via the P53 signaling pathway remains unclear. In this study, we found that FEZF1-AS1 promotes the growth of the CRC cell line (HCT116) and drives epithelial-mesenchymal transition (EMT) through the P53 signaling pathway. Our data showed that FEZF1-AS1 expression is significantly upregulated in HCT116, and elevated levels of FEZF1-AS1 are associated with poor prognosis in patients with CRC. In addition, the knockdown of FEZF1-AS1 markedly inhibited the proliferation of HCT116 by inducing cell cycle arrest. Knockdown of FEZF1-AS1 depletion also led to apoptosis in CRC cells by suppressing the P53 signaling pathway and EMT, thereby reducing their viability, proliferation, migration, and invasion. In summary, this study confirmed that FEZF1-AS1 regulates the growth of junction HCT116 through P53 signaling pathway and inhibiting EMT, providing new insights for the potential therapeutic strategies against CRC.
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