聚焦羊膜提取物滴眼液:文献综述。

IF 2 4区 医学 Q2 OPHTHALMOLOGY
Raphael Kilian, Erika Bonacci, Ruth Donner, Jan Lammer, Clara Rizzo, Emanuele Crincoli, Valentino De Ruvo, Gerald Schmidinger, Emilio Pedrotti, Giorgio Marchini
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引用次数: 0

摘要

目的:回顾有关羊膜提取物滴眼液(AMEDs)治疗眼表疾病有效性的文献:综述有关羊膜提取物滴眼液(AMEDs)治疗眼表疾病有效性的文献:方法:检索 PubMed/MEDLINE、Scopus 和 CENTRAL 数据库,直至 2024 年 3 月 4 日。我们共发现了 1,121 项研究,其中 26 项被选作全文综述。有 12 项研究符合纳入标准,并对临床改善情况、角膜染色消退时间、不良事件和制备方法进行了分析。根据牛津循证医学中心对临床数据的强度进行了分级:总的来说,205 名患者的 296 只眼睛使用了 AMED 复合物。其中 59% 的眼睛接受了干眼症治疗,23% 的眼睛接受了上皮缺损治疗,其余(18%)的眼睛接受了其他角膜伤口愈合疾病治疗。研究人员介绍了三种主要的眼药水制备方法,即冻干、均质和新鲜 AMED。虽然结果报告的方法不尽相同,但所有纳入的研究都显示了不同程度的症状和体征改善。眼部副作用的总体发生率为 2.3%:尽管证据质量不够理想,但总体而言,现有文献表明,AMED 是治疗眼表疾病的重要工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Spotlight on Amniotic Membrane Extract Eye Drops: A Review of the Literature.

Objective: To review the literature focusing on the effectiveness of amniotic membrane extract eye drops (AMEDs) in the treatment of ocular surface diseases.

Methods: PubMed/MEDLINE, Scopus, and CENTRAL databases were searched until March 4, 2024. Overall, we identified 1,121 studies, 26 of which were selected for a full-text review. Twelve studies met the inclusion criteria and were analyzed for clinical improvements, time to resolution of corneal staining, adverse events, and preparation methods. Strength of clinical data was graded according to the Oxford Center for Evidence-Based Medicine.

Results: Overall, AMED compounds were used in 296 eyes of 205 patients. Fifty-nine percent of eyes were treated for dry eye disease, 23% for an epithelial defect, and the rest (18%) for other corneal wound healing disorders. Three main types of eye drops preparation were described, that is, lyophilized, homogenized, and fresh AMED. Although the methods of outcome reporting were heterogeneous, all included studies showed various grades of improvement in both signs and symptoms. The overall incidence of ocular side effects was 2.3%.

Conclusions: Despite the suboptimal quality of evidence, overall, the available literature suggests that AMED is a valuable tool in the treatment of ocular surface disorders.

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来源期刊
CiteScore
4.50
自引率
4.30%
发文量
150
审稿时长
6-12 weeks
期刊介绍: Eye & Contact Lens: Science and Clinical Practice is the official journal of the Contact Lens Association of Ophthalmologists (CLAO), an international educational association for anterior segment research and clinical practice of interest to ophthalmologists, optometrists, and other vision care providers and researchers. Focusing especially on contact lenses, it also covers dry eye disease, MGD, infections, toxicity of drops and contact lens care solutions, topography, cornea surgery and post-operative care, optics, refractive surgery and corneal stability (eg, UV cross-linking). Peer-reviewed and published six times annually, it is a highly respected scientific journal in its field.
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