Amy E Ensing, Henok Getahun, Rebecca Z Lin, Amy L Zhang, Emma K Landes, Judith E C Lieu
{"title":"探索小儿阻塞性睡眠呼吸暂停严重程度与生活质量之间的关系。","authors":"Amy E Ensing, Henok Getahun, Rebecca Z Lin, Amy L Zhang, Emma K Landes, Judith E C Lieu","doi":"10.1002/lary.31893","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the relationship between pediatric obstructive sleep apnea (OSA) severity and quality of life (QOL).</p><p><strong>Study design: </strong>This study was a cross-sectional survey.</p><p><strong>Methods: </strong>Patients aged 2-18 years being evaluated for OSA were recruited from a pediatric otolaryngology clinic and sleep center. Participants completed the Obstructive Sleep Apnea Questionnaire (OSA-18) and the PedsQL™ Multidimensional Fatigue Score (MFS).</p><p><strong>Results: </strong>Responses of 18 control participants without OSA, 26 participants with clinically resolved OSA, 19 with non-obstructive sleep disordered breathing (SDB), 29 with mild OSA, 21 with moderate OSA, and 27 with severe OSA were analyzed. OSA-18 scores for controls were lower (indicating higher QOL) than patients with SDB (mean difference [MD] = -31.1; 95% CI -42.7 to -19.5), mild OSA (MD = -30.4; 95% CI -40.1 to -20.7), moderate OSA (MD = -23.6; 95% CI -34.5 to -12.7), or severe OSA (MD = -40.1; 95% CI -50.0 to -30.2). Participants with resolved OSA also had lower OSA-18 scores than participants in the SDB and OSA groups. Few differences were observed between the SDB, mild OSA, moderate OSA, and severe OSA groups on either the OSA-18 or PedsQL MFS, and these did not demonstrate a clear pattern. Linear regression of apnea hypopnea index (AHI) and OSA-18 or PedsQL MFS scores revealed weak relationships (R<sup>2</sup> < 0.1).</p><p><strong>Conclusion: </strong>Using both an OSA-specific measure and generic fatigue measure, no consistent differences in QOL scores were found between children with varying OSA severities. Therefore, disease burden in pediatric patients with mild OSA and SDB should not be underestimated.</p><p><strong>Level of evidence: </strong>Level 3 Laryngoscope, 2024.</p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the Association Between Pediatric Obstructive Sleep Apnea Severity and Quality of Life.\",\"authors\":\"Amy E Ensing, Henok Getahun, Rebecca Z Lin, Amy L Zhang, Emma K Landes, Judith E C Lieu\",\"doi\":\"10.1002/lary.31893\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To investigate the relationship between pediatric obstructive sleep apnea (OSA) severity and quality of life (QOL).</p><p><strong>Study design: </strong>This study was a cross-sectional survey.</p><p><strong>Methods: </strong>Patients aged 2-18 years being evaluated for OSA were recruited from a pediatric otolaryngology clinic and sleep center. Participants completed the Obstructive Sleep Apnea Questionnaire (OSA-18) and the PedsQL™ Multidimensional Fatigue Score (MFS).</p><p><strong>Results: </strong>Responses of 18 control participants without OSA, 26 participants with clinically resolved OSA, 19 with non-obstructive sleep disordered breathing (SDB), 29 with mild OSA, 21 with moderate OSA, and 27 with severe OSA were analyzed. OSA-18 scores for controls were lower (indicating higher QOL) than patients with SDB (mean difference [MD] = -31.1; 95% CI -42.7 to -19.5), mild OSA (MD = -30.4; 95% CI -40.1 to -20.7), moderate OSA (MD = -23.6; 95% CI -34.5 to -12.7), or severe OSA (MD = -40.1; 95% CI -50.0 to -30.2). Participants with resolved OSA also had lower OSA-18 scores than participants in the SDB and OSA groups. Few differences were observed between the SDB, mild OSA, moderate OSA, and severe OSA groups on either the OSA-18 or PedsQL MFS, and these did not demonstrate a clear pattern. Linear regression of apnea hypopnea index (AHI) and OSA-18 or PedsQL MFS scores revealed weak relationships (R<sup>2</sup> < 0.1).</p><p><strong>Conclusion: </strong>Using both an OSA-specific measure and generic fatigue measure, no consistent differences in QOL scores were found between children with varying OSA severities. Therefore, disease burden in pediatric patients with mild OSA and SDB should not be underestimated.</p><p><strong>Level of evidence: </strong>Level 3 Laryngoscope, 2024.</p>\",\"PeriodicalId\":49921,\"journal\":{\"name\":\"Laryngoscope\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-11-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Laryngoscope\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/lary.31893\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Laryngoscope","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/lary.31893","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
摘要
研究目的调查小儿阻塞性睡眠呼吸暂停（OSA）严重程度与生活质量（QOL）之间的关系：研究设计：本研究为横断面调查：方法：从儿科耳鼻喉科诊所和睡眠中心招募 2-18 岁接受 OSA 评估的患者。参与者填写阻塞性睡眠呼吸暂停问卷（OSA-18）和 PedsQL™ 多维疲劳评分（MFS）：分析了 18 名无 OSA 的对照组参与者、26 名临床治愈的 OSA 患者、19 名非阻塞性睡眠呼吸障碍 (SDB)患者、29 名轻度 OSA 患者、21 名中度 OSA 患者和 27 名重度 OSA 患者的回答。对照组患者的 OSA-18 评分低于 SDB（平均差 [MD] = -31.1；95% CI -42.7 至 -19.5）、轻度 OSA（MD = -30.4；95% CI -40.1 至 -20.7）、中度 OSA（MD = -23.6；95% CI -34.5 至 -12.7）或重度 OSA（MD = -40.1；95% CI -50.0 至 -30.2）患者（表明 QOL 较高）。与 SDB 组和 OSA 组的参与者相比，OSA-18 分值也较低。SDB组、轻度OSA组、中度OSA组和重度OSA组在OSA-18或PedsQL MFS上几乎没有差异，而且这些差异也没有表现出明显的模式。呼吸暂停低通气指数（AHI）与 OSA-18 或 PedsQL MFS 分数的线性回归显示出微弱的关系（R2 结论）：通过使用 OSA 特异性测量方法和通用疲劳测量方法，没有发现不同 OSA 严重程度的儿童在 QOL 分数上存在一致的差异。因此，不应低估轻度 OSA 和 SDB 儿童患者的疾病负担：3级 《喉镜》，2024年。
Exploring the Association Between Pediatric Obstructive Sleep Apnea Severity and Quality of Life.
Objectives: To investigate the relationship between pediatric obstructive sleep apnea (OSA) severity and quality of life (QOL).
Study design: This study was a cross-sectional survey.
Methods: Patients aged 2-18 years being evaluated for OSA were recruited from a pediatric otolaryngology clinic and sleep center. Participants completed the Obstructive Sleep Apnea Questionnaire (OSA-18) and the PedsQL™ Multidimensional Fatigue Score (MFS).
Results: Responses of 18 control participants without OSA, 26 participants with clinically resolved OSA, 19 with non-obstructive sleep disordered breathing (SDB), 29 with mild OSA, 21 with moderate OSA, and 27 with severe OSA were analyzed. OSA-18 scores for controls were lower (indicating higher QOL) than patients with SDB (mean difference [MD] = -31.1; 95% CI -42.7 to -19.5), mild OSA (MD = -30.4; 95% CI -40.1 to -20.7), moderate OSA (MD = -23.6; 95% CI -34.5 to -12.7), or severe OSA (MD = -40.1; 95% CI -50.0 to -30.2). Participants with resolved OSA also had lower OSA-18 scores than participants in the SDB and OSA groups. Few differences were observed between the SDB, mild OSA, moderate OSA, and severe OSA groups on either the OSA-18 or PedsQL MFS, and these did not demonstrate a clear pattern. Linear regression of apnea hypopnea index (AHI) and OSA-18 or PedsQL MFS scores revealed weak relationships (R2 < 0.1).
Conclusion: Using both an OSA-specific measure and generic fatigue measure, no consistent differences in QOL scores were found between children with varying OSA severities. Therefore, disease burden in pediatric patients with mild OSA and SDB should not be underestimated.
期刊介绍：
The Laryngoscope has been the leading source of information on advances in the diagnosis and treatment of head and neck disorders since 1890. The Laryngoscope is the first choice among otolaryngologists for publication of their important findings and techniques. Each monthly issue of The Laryngoscope features peer-reviewed medical, clinical, and research contributions in general otolaryngology, allergy/rhinology, otology/neurotology, laryngology/bronchoesophagology, head and neck surgery, sleep medicine, pediatric otolaryngology, facial plastics and reconstructive surgery, oncology, and communicative disorders. Contributions include papers and posters presented at the Annual and Section Meetings of the Triological Society, as well as independent papers, "How I Do It", "Triological Best Practice" articles, and contemporary reviews. Theses authored by the Triological Society’s new Fellows as well as papers presented at meetings of the American Laryngological Association are published in The Laryngoscope.
• Broncho-esophagology
• Communicative disorders
• Head and neck surgery
• Plastic and reconstructive facial surgery
• Oncology
• Speech and hearing defects
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