群体免疫措施可预测2017-2018流感季甲型流感(H3N2)的优势支系,并揭示与年龄相关的易感性和抗体结合特异性差异。

IF 4.3 4区 医学 Q1 INFECTIOUS DISEASES
Kangchon Kim, Marcos C. Vieira, Sigrid Gouma, Madison E. Weirick, Scott E. Hensley, Sarah Cobey
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引用次数: 0

摘要

背景:对于抗原可变的病原体(如流感)而言,菌株的适应性在一定程度上取决于与其他菌株相比,宿主是否相对容易感染该菌株。针对血凝素(HA)和神经氨酸酶(NA)的抗体可在很大程度上防止流感感染。我们的问题是,从横断面抗体得出的人群对甲型 H3N2 流感不同支系的易感性估计值能否预测下一季支系的成功率:我们在 2017 年夏季收集了 483 名 1 至 90 岁健康人的血清,并使用聚焦还原中和试验(FNRT)和酶联凝集素检测法(ELLA)分析了代表性毒株 HA 和 NA 的中和反应。我们估计了人群对循环病毒支系的相对平均易感性和特定年龄易感性,并将这些估计值与接下来的 2017-2018 年季节中支系频率的变化进行了比较:结果:中和抗体滴度最低的支系在下一季占主导地位,表明人群对该支系的易感性更高。病毒株之间的滴度相关性因年龄而异,这表明在过去共同暴露的驱动下,表位靶向存在与年龄相关的差异。然而,年龄组内仍存在大量无法解释的差异:这项研究表明,具有代表性的群体免疫措施可以改善进化预测,并为流感的选择性压力提供信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Measures of Population Immunity Can Predict the Dominant Clade of Influenza A (H3N2) in the 2017–2018 Season and Reveal Age-Associated Differences in Susceptibility and Antibody-Binding Specificity

Measures of Population Immunity Can Predict the Dominant Clade of Influenza A (H3N2) in the 2017–2018 Season and Reveal Age-Associated Differences in Susceptibility and Antibody-Binding Specificity

Background

For antigenically variable pathogens such as influenza, strain fitness is partly determined by the relative availability of hosts susceptible to infection with that strain compared with others. Antibodies to the hemagglutinin (HA) and neuraminidase (NA) confer substantial protection against influenza infection. We asked if a cross-sectional antibody-derived estimate of population susceptibility to different clades of influenza A (H3N2) could predict the success of clades in the following season.

Methods

We collected sera from 483 healthy individuals aged 1 to 90 years in the summer of 2017 and analyzed neutralizing responses to the HA and NA of representative strains using focus reduction neutralization tests (FNRT) and enzyme-linked lectin assays (ELLA). We estimated relative population-average and age-specific susceptibilities to circulating viral clades and compared those estimates to changes in clade frequencies in the following 2017–2018 season.

Results

The clade to which neutralizing antibody titers were lowest, indicating greater population susceptibility, dominated the next season. Titer correlations between viral strains varied by age, suggesting age-associated differences in epitope targeting driven by shared past exposures. Yet substantial unexplained variation remains within age groups.

Conclusions

This study indicates how representative measures of population immunity might improve evolutionary forecasts and inform selective pressures on influenza.

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来源期刊
CiteScore
7.20
自引率
4.50%
发文量
120
审稿时长
6-12 weeks
期刊介绍: Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.
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