通过补体激活的经典途径控制Torque Teno病毒--使用Sutimlimab的首次人体试验的回顾性分析。

IF 6.8 3区 医学 Q1 VIROLOGY
Sebastian Kapps, Jakob Mühlbacher, Dorian Kulifaj, Sophie Courjal, Farsad Eskandary, Martin Schiemann, Bernd Jilma, Georg A. Böhmig, Gregor Bond, Markus Wahrmann
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引用次数: 0

摘要

特诺病毒(TTV)的载量与其宿主免疫系统的功能有关,因此被认为是一种潜在的免疫调节疗法监测工具。然而,人们对 TTV 控制的免疫学机制尚不完全了解。为了评估经典补体途径对 TTV 的影响,研究人员通过 qPCR 分析了 64 名健康志愿者和 10 名接受抗 C1s 抗体 sutimlimab 治疗的肾移植受者的血清 TTV 拷贝数(c/mL)。总体而言,观察到 sutimlimab 引起的补体活性降低与 TTV 负荷增加之间存在相关性(ρ = -0.367,p 10 c/mL,四分位数间距 [IQR] 2.8-4.4 vs. 2.9 log10 c/mL,0.8-3.5;p = 0.063)。多次施用低剂量(30 毫克/千克)也显示,健康志愿者的 TTV 负荷有增加趋势(1.8 log10 c/mL, 0-2.3 vs. 1.9, 1.3-2.8; p = 0.054),而移植受者的 TTV 负荷则显著增加(3.5 log10 c/mL, 3.0-6.1 vs. 4.1, 3.5-6.4; p = 0.004)。该报告表明经典补体途径在控制 TTV 负荷方面发挥作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Torque Teno Virus Control by the Classical Pathway of Complement Activation—A Retrospective Analysis From a First-in-Human Trial Utilizing Sutimlimab

Torque Teno virus (TTV) load is linked with the functionality of its host's immune system and has been proposed as a potential monitoring tool for immune-modulating therapy. However, the immunological mechanisms of TTV control are incompletely understood. To assess the effect of the classical complement pathway on TTV, 64 healthy volunteers and 10 kidney transplant recipients treated with the anti-C1s antibody sutimlimab were analyzed for serum TTV copy numbers (c/mL) by qPCR. Overall, a correlation was observed between the decrease in complement activity caused by sutimlimab and the TTV load increase (ρ = −0.367, p < 0.001). Subgroup analysis indicated a trend toward TTV load increase in healthy volunteers following the highest sutimlimab dose compared to baseline (100 mg/kg body weight; median 3.5 log10 c/mL, interquartile range [IQR] 2.8–4.4 vs. 2.9 log10 c/mL, 0.8–3.5; p = 0.063). Administering multiple lower doses (30 mg/kg) also showed a trend toward TTV load increase in healthy volunteers (1.8 log10 c/mL, 0–2.3 vs. 1.9, 1.3–2.8; p = 0.054) and a significant increase in transplant recipients (3.5 log10 c/mL, 3.0–6.1 vs. 4.1, 3.5–6.4; p = 0.004). This report suggests a role for the classical complement pathway in controlling TTV load.

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来源期刊
Journal of Medical Virology
Journal of Medical Virology 医学-病毒学
CiteScore
23.20
自引率
2.40%
发文量
777
审稿时长
1 months
期刊介绍: The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.
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