Dongxue Liu, Liu Yang, Peiqi Liu, Yujiao Wang, Lan Gao
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To clarify this issue and provide evidence supporting the primary prevention of stroke in young people, this systematic review and meta-analysis summarizes the latest findings from previous studies.</p><p><strong>Methods: </strong>A systematic search of PubMed, EMBASE, Cochrane Library, and Web of Science databases was conducted until April 2023. The review included observational studies comparing stroke risk estimates between cannabis abusers and non-users.</p><p><strong>Results: </strong>This review included six observational studies focusing on cannabis abuse, involving 119,284,152 participants. A significant association was found between cannabis abuse and an increased risk of stroke [OR = 1.14, 95% CI (1.08, 1.20)]. However, there was substantial heterogeneity among the studies (<i>I</i> <sup>2</sup> = 89%, <i>p</i> < 0.001). After adjusting for confounders such as smoking and alcohol abuse, we found a stronger association between cannabis abuse and stroke in young adults [OR = 1.21, 95% CI (1.12, 1.29)]. Subgroup analyses revealed no significant difference in stroke risk between ischemic and hemorrhagic strokes (<i>p</i> = 0.43).</p><p><strong>Conclusion: </strong>The results of our systematic review and meta-analysis showed that cannabis abuse has a more significant effect on the occurrence of stroke in young people; however, it was not possible to distinguish whether cannabis abuse is more likely to cause ischemic or hemorrhagic stroke. Further research is needed to explore the impact of different drug types, dosages, and behaviors on stroke risk.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/, Identifier CRD42023443261.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1426023"},"PeriodicalIF":2.7000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536518/pdf/","citationCount":"0","resultStr":"{\"title\":\"Impact of cannabis abuse on the occurrence of stroke in young people: a systematic review and meta-analysis.\",\"authors\":\"Dongxue Liu, Liu Yang, Peiqi Liu, Yujiao Wang, Lan Gao\",\"doi\":\"10.3389/fneur.2024.1426023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The occurrence of stroke in young people has risen significantly. 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引用次数: 0
摘要
背景：青少年中风的发病率大幅上升。这很容易导致肢体残疾、吞咽困难和认知障碍等问题，对家庭和社会产生深远影响。青少年中风的危险因素与传统中风的危险因素不同，其中滥用大麻是一个重要的高危因素。然而，滥用大麻对青少年中风发生率和致残率的影响程度仍不清楚。为了澄清这一问题并提供支持青少年中风一级预防的证据，本系统综述和荟萃分析总结了以往研究的最新发现：方法：对 PubMed、EMBASE、Cochrane Library 和 Web of Science 数据库进行了系统检索，检索期至 2023 年 4 月。综述包括比较大麻滥用者和非大麻滥用者中风风险估计值的观察性研究：本综述包括六项以大麻滥用为重点的观察性研究，涉及 119 284 152 名参与者。研究发现，滥用大麻与中风风险增加之间存在明显关联[OR = 1.14，95% CI (1.08，1.20)]。然而，各研究之间存在很大的异质性（I 2 = 89%，P P = 0.43）：我们的系统综述和荟萃分析结果表明，滥用大麻对年轻人中风的发生有更显著的影响；但无法区分滥用大麻更有可能导致缺血性中风还是出血性中风。需要进一步研究探讨不同药物类型、剂量和行为对中风风险的影响。系统综述注册：https://www.crd.york.ac.uk/prospero/，标识符 CRD42023443261。
Impact of cannabis abuse on the occurrence of stroke in young people: a systematic review and meta-analysis.
Background: The occurrence of stroke in young people has risen significantly. This can easily lead to physical disabilities, swallowing difficulties, and cognitive impairment, among other issues, having a profound impact on families and society. Risk factors for stroke in young people differ from those for traditional stroke, with cannabis abuse emerging as a significant high-risk factor. However, the extent of the impact of cannabis abuse on the occurrence of stroke and the rate of disability in young people remains unclear. To clarify this issue and provide evidence supporting the primary prevention of stroke in young people, this systematic review and meta-analysis summarizes the latest findings from previous studies.
Methods: A systematic search of PubMed, EMBASE, Cochrane Library, and Web of Science databases was conducted until April 2023. The review included observational studies comparing stroke risk estimates between cannabis abusers and non-users.
Results: This review included six observational studies focusing on cannabis abuse, involving 119,284,152 participants. A significant association was found between cannabis abuse and an increased risk of stroke [OR = 1.14, 95% CI (1.08, 1.20)]. However, there was substantial heterogeneity among the studies (I2 = 89%, p < 0.001). After adjusting for confounders such as smoking and alcohol abuse, we found a stronger association between cannabis abuse and stroke in young adults [OR = 1.21, 95% CI (1.12, 1.29)]. Subgroup analyses revealed no significant difference in stroke risk between ischemic and hemorrhagic strokes (p = 0.43).
Conclusion: The results of our systematic review and meta-analysis showed that cannabis abuse has a more significant effect on the occurrence of stroke in young people; however, it was not possible to distinguish whether cannabis abuse is more likely to cause ischemic or hemorrhagic stroke. Further research is needed to explore the impact of different drug types, dosages, and behaviors on stroke risk.
期刊介绍：
The section Stroke aims to quickly and accurately publish important experimental, translational and clinical studies, and reviews that contribute to the knowledge of stroke, its causes, manifestations, diagnosis, and management.
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