纳米马达作为治疗剂:推进炎症相关疾病的治疗策略。

IF 7 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Min Luo, Fu-Kun Zhao, Yuan-Min Wang, Yong Luo
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引用次数: 0

摘要

炎症是机体对病原体、受损细胞或刺激物等有害刺激的一种生理反应,涉及一系列细胞和分子事件。炎症与神经退行性疾病、癌症和动脉粥样硬化等多种疾病有关,是导致全球死亡的主要原因。主要的炎症因子,如肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、单核细胞趋化蛋白-1(MCP-1/CCL2)、RANTES(CCL5)和前列腺素,在炎症和疾病进展中发挥着核心作用。非甾体抗炎药、类固醇、生物制剂和抗氧化剂等传统治疗方法存在局限性。纳米材料的最新进展为治疗炎症相关疾病提供了前景广阔的解决方案。纳米材料依赖于被动靶向,在精确给药方面面临挑战,与之不同的是,由化学或光学刺激驱动的纳米马达提供了一种更动态的方法,它能主动导航到炎症部位,从而提高给药效率和治疗效果。纳米马达可根据特定的环境变化(如 pH 值和炎症因子)控制药物释放,确保药物在疾病部位的有效浓度。与传统治疗方法相比,这种主动靶向能力能够使用较小的药物剂量,从而减少药物的总体用量、成本和潜在副作用。通过提高精确度和效率,纳米马达解决了传统疗法的局限性,是治疗炎症相关疾病的一大进步。本综述总结了纳米电机介导的炎症相关疾病治疗的最新研究,并讨论了优化其临床转化的挑战和未来方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanomotors as Therapeutic Agents: Advancing Treatment Strategies for Inflammation-Related Diseases.

Inflammation is a physiological response of the body to harmful stimuli such as pathogens, damaged cells, or irritants, involving a series of cellular and molecular events. It is associated with various diseases including neurodegenerative disorders, cancer, and atherosclerosis, and is a leading cause of global mortality. Key inflammatory factors, such as Tumor Necrosis Factor-alpha (TNF-α), Interleukin-1 (IL-1), Interleukin-6 (IL-6), Monocyte Chemoattractant Protein-1 (MCP-1/CCL2), RANTES (CCL5), and prostaglandins, play central roles in inflammation and disease progression. Traditional treatments such as NSAIDs, steroids, biologic agents, and antioxidants have limitations. Recent advancements in nanomaterials present promising solutions for treating inflammation-related diseases. Unlike nanomaterials that rely on passive targeting and face challenges in precise drug delivery, nanomotors, driven by chemical or optical stimuli, offer a more dynamic approach by actively navigating to inflammation sites, thereby enhancing drug delivery efficiency and therapeutic outcomes. Nanomotors allow for controlled drug release in response to specific environmental changes, such as pH and inflammatory factors, ensuring effective drug concentrations at disease sites. This active targeting capability enables the use of smaller drug doses, which reduces overall drug usage, costs, and potential side effects compared to traditional treatments. By improving precision and efficiency, nanomotors address the limitations of conventional therapies and represent a significant advancement in the treatment of inflammation-related diseases. This review summarizes the latest research on nanomotor-mediated treatment of inflammation-related diseases and discusses the challenges and future directions for optimizing their clinical translation.

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来源期刊
Chemical record
Chemical record 化学-化学综合
CiteScore
11.00
自引率
3.00%
发文量
188
审稿时长
>12 weeks
期刊介绍: The Chemical Record (TCR) is a "highlights" journal publishing timely and critical overviews of new developments at the cutting edge of chemistry of interest to a wide audience of chemists (2013 journal impact factor: 5.577). The scope of published reviews includes all areas related to physical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, polymer chemistry, materials chemistry, bioorganic chemistry, biochemistry, biotechnology and medicinal chemistry as well as interdisciplinary fields. TCR provides carefully selected highlight papers by leading researchers that introduce the author''s own experimental and theoretical results in a framework designed to establish perspectives with earlier and contemporary work and provide a critical review of the present state of the subject. The articles are intended to present concise evaluations of current trends in chemistry research to help chemists gain useful insights into fields outside their specialization and provide experts with summaries of recent key developments.
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