五味子中具有抑制 LPS 诱导的 NO 生成活性的小分子木酚素

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2024-11-05 DOI:10.1002/cbdv.202402354

Ping Sun, Xin-Cheng Zhuang, Rui Ao, Hua Zhang

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引用次数: 0

摘要

通过对五味子果实的植物化学研究，分离出七种新的次要木脂素，即五味子木脂素 A-G（1-7），包括一种苯并呋喃类（1）、三种芳基四氢呋喃类（2-4）和三种四氢呋喃类（5-7）。通过综合光谱分析确定了它们的结构，并利用电子圆二色性技术和量子化学计算方法确定了它们的绝对构型。值得注意的是，这是首次从盐肤木中发现正苯并呋喃和芳基四氢萘类木脂素。化合物 1、3 和 4 对脂多糖诱导的小鼠 RAW264.7 细胞产生一氧化氮有轻微的抑制作用。

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Minor Lignans with Inhibitory Activity against LPS-induced NO Production from Schisandra chinensis.

Phytochemical investigation into the fruits of Schisandra chinensis led to the isolation of seven new minor lignans, schisanchignans A-G (1-7), including one benzofuran type (1), three aryltetralin type (2-4) and three tetrahydrofuran type (5-7). Their structures were established by comprehensive spectroscopic analyses, and the absolute configurations were determined by electronic circular dichroism technique including quantum chemical calculation method. Of note, this is the first report of nor-benzofuran and aryltetralin types of lignans from S. chinensis. Compounds 1, 3 and 4 exhibited mild inhibitory activity against the lipopolysaccharide-induced production of nitric oxide in murine RAW264.7 cells.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.