影响一个家庭三代人慢性乙型肝炎感染的宿主和病毒因素。

IF 2.3 3区 生物学 Q3 MICROBIOLOGY
Malihe Naderi, Seyed Masoud Hosseini, Naser Behnampour, Sima Besharat, Iraj Shahramian, Masoud Khoshnia, Abdolvahab Moradi
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引用次数: 0

摘要

慢性乙型肝炎(CHB)感染受病毒学和宿主因素的影响。研究人员根据 HBV 血清标志物将 5,920 名慢性乙型肝炎患者分为四组:三代同堂家庭(慢性乙型肝炎祖母、母亲和子女)、两代同堂家庭(慢性乙型肝炎母亲/子女配对)、HBV 感染康复者和对照组。血清学标记物、病毒载量、肝功能检测(LFT)、HBV 基因突变、HLA-DQ 变异、细胞因子多态性以及肝脏硬度测量(LSM)均使用 FibroScan 进行分析。在 30% 的三代组和 20% 的二代组中观察到了核心/前核心(G1896A/G1899A)、聚合酶(H248N、H267Q、N263D)、S(G145R、S143L)和 X(C1500T、T1464C)等基因的点突变。三代组的平均肝硬度测量值(LSM)最高(4.94 ± 1.24 kPa),这被认为是肝细胞癌(HCC)发病的预测指标。随后的 HLA 等位基因分析发现,HLA-DQB105:01(OR = 0.27)是耐药的危险因素,而 HLA-DQB105 (OR = 0.98)、HLA-DQB103 (OR = 0.80)和 HLA-DQB104:01 (OR = 0.70)与三代组和二代组的 HBV 持续存在相关。更高频率的特定多态性,包括 G/G(TNF-α:75%;IL-18:74%)、A/A(IL-10:74.28%)和 C/C(IL-1ß:80%),与持续感染显著相关。对病毒序列、HLA-DQB1 变异、细胞因子多态性和系统发育树中的遗传关系的分析表明,三代家族中有 40% 的慢性阻塞性肺病患者是由共同的传播源感染的,表现为存在相同的 HBV 基因型。这项研究强调了影响乙型肝炎感染结果的宿主和病毒因素之间复杂的相互作用,并提出了潜在的家族传播途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Host and Viral Factors Influencing Chronic Hepatitis B Infection Across Three Generations in a Family.

Chronic hepatitis B (CHB) infection is influenced by both virological and host factors. A total of 5,920 CHB patients were classified into four groups based on HBV seromarkers: three-generation families (CHB grandmother, mother, and child), two-generation families (CHB mother/child pairs), individuals recovered from HBV infection, and a control group. Serological markers, viral load, liver function tests (LFT), HBV mutations, HLA-DQ variations, cytokine polymorphisms, and liver stiffness measurements (LSM) were analyzed using FibroScan. Point mutations in genes such as core/pre-core (G1896A/G1899A), polymerase (H248N, H267Q, N263D), S (G145R, S143L), and X (C1500T, T1464C) were observed in 30% of three-generation pairs and 20% of two-generation pairs. The three-generation group exhibited the highest mean liver stiffness measurement (LSM) (4.94 ± 1.24 kPa), which is considered a predictor for the development of hepatocellular carcinoma (HCC). Subsequent HLA allele analysis identified HLA-DQB105:01 (OR = 0.27) as a risk factor for treatment resistance, while HLA-DQB105 (OR = 0.98), HLA-DQB103 (OR = 0.80), and HLA-DQB104:01 (OR = 0.70) were associated with HBV persistence in both three- and two-generation groups. Higher frequencies of specific polymorphisms, including G/G (TNF-α: 75%; IL-18: 74%), A/A (IL-10: 74.28%), and C/C (IL-1ß: 80%), were significantly linked to persistent infection. Analysis of viral sequences, HLA-DQB1 variations, cytokine polymorphisms, and genetic relationships within the phylogenetic tree revealed that 40% of CHB patients from three-generation families were infected by a shared source of transmission, as indicated by the presence of the same HBV genotype. This study underscores the complex interplay of host and viral factors that influence hepatitis B infection outcomes and suggests potential familial transmission pathways.

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来源期刊
Current Microbiology
Current Microbiology 生物-微生物学
CiteScore
4.80
自引率
3.80%
发文量
380
审稿时长
2.5 months
期刊介绍: Current Microbiology is a well-established journal that publishes articles in all aspects of microbial cells and the interactions between the microorganisms, their hosts and the environment. Current Microbiology publishes original research articles, short communications, reviews and letters to the editor, spanning the following areas: physiology, biochemistry, genetics, genomics, biotechnology, ecology, evolution, morphology, taxonomy, diagnostic methods, medical and clinical microbiology and immunology as applied to microorganisms.
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