BCAA 与 2 型糖尿病患者内脏脂肪面积的关系比皮下脂肪面积更密切:一项横断面研究。

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Xinghua Cai, Wenmin Li, Liang Wang, Yingying Shi, Jie Gao, Hongping Wang, Tao Lei, Jun Lu
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引用次数: 0

摘要

背景:有报道称支链氨基酸(BCAA)与肥胖有关,但在2型糖尿病患者中,BCAA与内脏脂肪面积(VFA)和皮下脂肪面积(SFA)的关系仍不清楚:这项横断面研究在 284 名 2 型糖尿病患者中进行。采用酶联免疫特异性测定法测量血清 BCAA 和支链酮酸 (BCKA) 的水平。用生物阻抗分析方法测量了VFA和SFA。采用皮尔逊相关分析和多变量线性回归分析计算了 BCAA 和 VFA 之间的关系:结论:血清 BCAA 水平与 VFA 的相关性比与 SFA 的相关性更密切,应开展前瞻性研究,进一步探讨 BCAA 与人类内脏脂肪堆积的中介机制:不适用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
BCAA was more closely associated with visceral fat area than subcutaneous fat area in patients of type 2 diabetes mellitus: a cross-sectional study.

Background: Branched-chain amino acid (BCAA) has been reported to be associated with obesity, the association of BCAA with visceral fat area (VFA) and subcutaneous fat area (SFA) remained unclear in patients with type 2 diabetes.

Methods: This cross-sectional study was conducted in 284 patients with type 2 diabetes mellitus. Enzyme-linked immunospecific assay was used to measure levels of serum BCAA and branched-chain keto acid (BCKA). VFA and SFA were measured with bio-impedance analysis method. The association between BCAA and VFA was calculated using Pearson correlation and multivariable linear regression analysis.

Results: There were significant differences in the means of body mass index, waist circumstance, SFA and VFA among the three groups divided by total BCAA tertiles (all p < 0.05). Compared to patients with lower levels of serum BCAA (the lower tertile group), the means of VFA and SFA were significantly larger in the middle and upper tertile groups (all p < 0.05). However, the differences in above obesity parameters were nonsignificant according to various BCKA tertiles. Pearson correlation analysis also demonstrated that BCAA levels were positive associated with each obesity parameter (p < 0.05). Nevertheless, multivariable linear regression analysis showed that levels of serum BCAA were correlated with VFA, BMI and WC (all p < 0.05) rather than SFA after adjusted for other confounders.

Conclusions: levels of serum BCAA were more closely correlated with VFA than SFA, prospective studies should be warranted to further explore the mechanism mediating BCAA and visceral fat accumulation in Human beings.

Clinical trial number: Not applicable.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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