近期重度抑郁障碍青少年的神经认知功能障碍:一项横断面比较研究。

IF 6 2区 医学 Q1 PEDIATRICS
Olga Bienek, Kelly Allott, Linda Antonucci, Alessandro Bertolino, Carolina Bonivento, Stephan Borgwardt, Paolo Brambilla, Katharine Chisholm, Udo Dannlowski, Theresa K Lichtenstein, Joseph Kambeitz, Lana Kambeitz-Ilankovic, Nikolaos Koutsouleris, Rebekka Lencer, Siân Lowri Griffiths, Eleonora Maggioni, Eva Meisenzahl, Christos Pantelis, Marlene Rosen, Stephan Ruhrmann, Raimo K R Salokangas, Alexandra Stainton, Marian Surmann, Rachel Upthegrove, Julian Wenzel, Stephen J Wood, Georg Romer, Jörg Michael Müller
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引用次数: 0

摘要

本研究旨在探讨与成年患者相比,青少年首次发作重度抑郁症(新近发病抑郁症,ROD)时的神经认知缺陷。研究分析了来自 PRONIA 研究基线评估的横断面神经认知数据,样本数为 650 人(55.31% 为女性)。在对 11 项神经认知测试进行主成分分析的基础上,我们得出了神经认知表现(NP)总分。我们采用 GLM 方法研究了健康对照组(HC)和 ROD 组之间以及青少年(15-21 岁)和成人(22-40 岁)之间的 NP 平均得分差异。这种方法考虑到了不平衡数据,在控制药物和教育年限影响的同时,重点关注了交互效应。我们的结果显示,与 HC 组相比,ROD 组的 NP 较低(d = - 0.29,p = .046),与成人组相比,青少年组的 NP 较低(d = - 0.29;p = .046)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neurocognitive dysfunction in adolescents with recent onset major depressive disorder: a cross-sectional comparative study.

The aim of this study was to examine the neurocognitive deficits associated with the first episode of major depressive disorder (recent onset depression, ROD) in adolescents as compared to adult patients. Cross-sectional neurocognitive data from the baseline assessments of the PRONIA study with N = 650 (55.31% females) were analyzed. Based on a principal component analysis of eleven neurocognitive tests, we constructed an overall neurocognitive performance (NP) score. We examined mean score differences in NP between the groups of healthy controls (HC) and ROD and between adolescents (15-21 years) and adults (22-40 years) within a GLM approach. This accounts for unbalanced data with focus on interaction effects while controlling for effects of medication and educational years. Our results show lower NP for the ROD as compared to the HC group (d = - 0.29, p = .046) and lower NP for the adolescent group as compared to the adult group (d = - 0.29; p < .039). There was no interaction between these two group effects (F = 1.11; p = .29). Our findings suggest that the detrimental effect of ROD on neurocognitive functioning is comparable in adolescent and adult patients, since lower scores in adolescent patients are explained by effects of age and education. Neurocognitive impairment is an under addressed issue in clinical treatment guidelines for adolescent MDD. We suggest efficient monitoring in clinical practice by using an aggregate of the Digit Symbol Substitution Test and the Trail Making Test B, which highly correlated with the overall score of NP (r = 0.82).

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来源期刊
CiteScore
12.80
自引率
4.70%
发文量
186
审稿时长
6-12 weeks
期刊介绍: European Child and Adolescent Psychiatry is Europe''s only peer-reviewed journal entirely devoted to child and adolescent psychiatry. It aims to further a broad understanding of psychopathology in children and adolescents. Empirical research is its foundation, and clinical relevance is its hallmark. European Child and Adolescent Psychiatry welcomes in particular papers covering neuropsychiatry, cognitive neuroscience, genetics, neuroimaging, pharmacology, and related fields of interest. Contributions are encouraged from all around the world.
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