缺血性中风后无用再灌注的时间和组织窗口

IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Zhe Cheng, Hongrui Wang, Xiaokun Geng, Gary B Rajah, Omar Elmadhoun, Guangge Peng, Yuchuan Ding
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引用次数: 0

摘要

血管溶栓和血栓切除术等再灌注策略是治疗急性缺血性中风的一线疗法。然而,只有一半的患者在大血管闭塞的血管内再灌注后实现了功能独立。及时恢复血流至关重要,但并非所有再灌注都能使患者获益,这种现象被称为徒劳再灌注。当脑组织在再灌注前已遭受不可逆转的损伤,或其他因素削弱了恢复血流的益处时,就会出现徒劳再灌注。这些因素包括再灌注未抢救损伤、再灌注诱发损伤和无回流现象。再灌注疗法的成功与否还取决于卒中后的时间和组织状况。更精确地定义这些时间窗和组织窗可以完善卒中干预,有可能扩大针对患者个体的有效再灌注机会,从而降低无用再灌注的发生率。本视角文章深入探讨了无效再灌注的复杂性以及时间窗和组织窗在决定卒中预后中的关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke.

Reperfusion strategies such as vascular thrombolysis and thrombectomy are the first-line treatments recommended for acute ischemic stroke. However, only half of these patients achieve functional independence after endovascular reperfusion of large vessel occlusions. Timely restoration of blood flow is crucial, but not all reperfusion results in benefit, a phenomenon termed futile reperfusion. Futile reperfusion occurs when brain tissue has already suffered irreversible damage before reperfusion or when other factors undermine the benefits of restored blood flow. These factors include reperfusion-not rescued injury, reperfusion-induced injury, and the no-reflow phenomenon. The success of reperfusion therapies also hinges on timing and tissue condition after stroke. Defining these time and tissue windows more precisely could refine stroke interventions, potentially expanding effective reperfusion opportunities tailored to individual patients, thereby reducing the incidence of futile reperfusion. This perspective article delves into the complexities of futile reperfusion and the critical roles of time and tissue windows in determining stroke outcomes.

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来源期刊
Aging and Disease
Aging and Disease GERIATRICS & GERONTOLOGY-
CiteScore
14.60
自引率
2.70%
发文量
138
审稿时长
10 weeks
期刊介绍: Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.
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