设计用于治疗炎症的细胞膜包裹纳米粒子。

IF 8 2区材料科学 Q1 CHEMISTRY, PHYSICAL

Nanoscale Horizons Pub Date : 2024-11-05 DOI:10.1039/d4nh00457d

Andreia Marinho, Salette Reis, Cláudia Nunes

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引用次数: 0

摘要

基于仿生学的给药系统（DDS）试图再现细胞间自然发生的复杂相互作用。细胞膜包被纳米颗粒（CMCNPs）是这一领域的主要策略之一，可防止蛋白溶解和清除。此外，用细胞膜包覆纳米粒子可使其获得母细胞固有的功能和特性。特别是在慢性炎症的情况下，根据应用的细胞类型，来自血液的细胞具有特殊的优势。因此，本综述将重点介绍利用血细胞膜针对和治疗炎症的生物仿生策略。

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On the design of cell membrane-coated nanoparticles to treat inflammatory conditions.

Biomimetic-based drug delivery systems (DDS) attempt to recreate the complex interactions that occur naturally between cells. Cell membrane-coated nanoparticles (CMCNPs) have been one of the main strategies in this area to prevent opsonization and clearance. Moreover, coating nanoparticles with cell membranes allows them to acquire functions and properties inherent to the mother cells. In particular, cells from bloodstream show to have specific advantages depending on the cell type to be used for that application, specifically in cases of chronic inflammation. Thus, this review focuses on the biomimetic strategies that use membranes from blood cells to target and treat inflammatory conditions.

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来源期刊

Nanoscale Horizons Materials Science-General Materials Science

CiteScore

16.30

自引率

1.00%

发文量

141

期刊介绍： Nanoscale Horizons stands out as a premier journal for publishing exceptionally high-quality and innovative nanoscience and nanotechnology. The emphasis lies on original research that introduces a new concept or a novel perspective (a conceptual advance), prioritizing this over reporting technological improvements. Nevertheless, outstanding articles showcasing truly groundbreaking developments, including record-breaking performance, may also find a place in the journal. Published work must be of substantial general interest to our broad and diverse readership across the nanoscience and nanotechnology community.