阑尾切除术标本中意外发现的局部大B细胞淋巴瘤伴有MYC和BCL6重排。

IF 2.2 4区医学 Q4 IMMUNOLOGY

Apmis Pub Date : 2024-11-05 DOI:10.1111/apm.13492

Przemyslaw Marcin Poltorak, Trine Lindhardt Plesner, Eva Stampe Petersson, Lone Schejbel, Marie Fredslund Breinholt, Lise Lode, Martin Hutchings, Peter Nørgaard

{"title":"阑尾切除术标本中意外发现的局部大B细胞淋巴瘤伴有MYC和BCL6重排。","authors":"Przemyslaw Marcin Poltorak, Trine Lindhardt Plesner, Eva Stampe Petersson, Lone Schejbel, Marie Fredslund Breinholt, Lise Lode, Martin Hutchings, Peter Nørgaard","doi":"10.1111/apm.13492","DOIUrl":null,"url":null,"abstract":"Large B-cell lymphomas (LBLs) comprise a genetically heterogeneous group of clinically aggressive non-Hodgkin lymphomas, frequently exhibiting overlapping features with diffuse large B-cell lymphoma and Burkitt's lymphoma. We report a case of a 24-year-old, previously healthy male with a classical clinical presentation of acute appendicitis. The pathologic examination discovered a large B-cell lymphoma with MYC and BCL6 rearrangements in the excised appendix. The patient was assigned Stage IEA, IPI = 0 and received chemotherapy. This case depicts a very uncommon occurrence of fully localized LBL in a patient of an unusually young age and clinical presentation for this type of lymphoma.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Localized large B-cell lymphoma with MYC and BCL6 rearrangements as an unexpected finding in an appendectomy specimen.\",\"authors\":\"Przemyslaw Marcin Poltorak, Trine Lindhardt Plesner, Eva Stampe Petersson, Lone Schejbel, Marie Fredslund Breinholt, Lise Lode, Martin Hutchings, Peter Nørgaard\",\"doi\":\"10.1111/apm.13492\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Large B-cell lymphomas (LBLs) comprise a genetically heterogeneous group of clinically aggressive non-Hodgkin lymphomas, frequently exhibiting overlapping features with diffuse large B-cell lymphoma and Burkitt's lymphoma. We report a case of a 24-year-old, previously healthy male with a classical clinical presentation of acute appendicitis. The pathologic examination discovered a large B-cell lymphoma with MYC and BCL6 rearrangements in the excised appendix. The patient was assigned Stage IEA, IPI = 0 and received chemotherapy. This case depicts a very uncommon occurrence of fully localized LBL in a patient of an unusually young age and clinical presentation for this type of lymphoma.\",\"PeriodicalId\":8167,\"journal\":{\"name\":\"Apmis\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-11-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Apmis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/apm.13492\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Apmis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/apm.13492","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

大 B 细胞淋巴瘤（LBLs）是一组遗传异质性的临床侵袭性非霍奇金淋巴瘤，经常表现出与弥漫大 B 细胞淋巴瘤和伯基特淋巴瘤重叠的特征。我们报告了一例 24 岁的健康男性病例，其典型临床表现为急性阑尾炎。病理检查在切除的阑尾中发现了大 B 细胞淋巴瘤，并伴有 MYC 和 BCL6 重排。患者被定为 IEA 期，IPI = 0，并接受了化疗。本病例描述了一种非常罕见的完全局部淋巴结转移性淋巴瘤，患者的年龄和临床表现对于这种类型的淋巴瘤来说都异常年轻。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Localized large B-cell lymphoma with MYC and BCL6 rearrangements as an unexpected finding in an appendectomy specimen.

Large B-cell lymphomas (LBLs) comprise a genetically heterogeneous group of clinically aggressive non-Hodgkin lymphomas, frequently exhibiting overlapping features with diffuse large B-cell lymphoma and Burkitt's lymphoma. We report a case of a 24-year-old, previously healthy male with a classical clinical presentation of acute appendicitis. The pathologic examination discovered a large B-cell lymphoma with MYC and BCL6 rearrangements in the excised appendix. The patient was assigned Stage IEA, IPI = 0 and received chemotherapy. This case depicts a very uncommon occurrence of fully localized LBL in a patient of an unusually young age and clinical presentation for this type of lymphoma.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Apmis 医学-病理学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： APMIS, formerly Acta Pathologica, Microbiologica et Immunologica Scandinavica, has been published since 1924 by the Scandinavian Societies for Medical Microbiology and Pathology as a non-profit-making scientific journal.