通过钯催化邻碘芳基烯烃的磺酰化合成吲哚基和苯并呋喃基苄基砜。

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

The Journal of Organic Chemistry Pub Date : 2024-11-06 DOI:10.1021/acs.joc.4c01953

Yuan Yin, Cangzhu Hu, Jing Sun, Kun Huang, Chao-Guo Yan, Lei Wang, Ying Han

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引用次数: 0

摘要

本研究描述了一种在温和条件下由钯催化的邻碘芳基烯与磺酸钠的高效多米诺偶联反应。这种新方法提供了一种实用的方案，通过在一锅中同时构建 C（sp2）-C（sp2）键和 C（sp3）-S 键来获得各种含吲哚和苯并呋喃的砜。这种转化方法的突出特点是操作简单、底物范围广、官能团耐受性好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of Indole- and Benzofuran-Based Benzylic Sulfones by Palladium-Catalyzed Sulfonylation of ortho-Iodoaryl Allenes.

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Synthesis of Indole- and Benzofuran-Based Benzylic Sulfones by Palladium-Catalyzed Sulfonylation of ortho-Iodoaryl Allenes.

A highly efficient palladium-catalyzed domino coupling reaction of ortho-iodoaryl allene with sodium sulfonates under mild conditions is described. This novel method provides a practical protocol to access diverse indole- and benzofuran-containing sulfones by simultaneous construction of C(sp²)-C(sp²) bond and a C(sp³)-S bonds in one pot. The salient features of this transformation include simple operations, broad substrate scope, and good functional group tolerance.

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来源期刊

The Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.