定制双酰基氧化膦，用于在生物系统中精确诱导氧化应激介导的细胞死亡。

IF 3.5 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

ACS Chemical Biology Pub Date : 2024-11-05 DOI:10.1021/acschembio.4c00399

Karim Almahayni, Jana Bachir Salvador, Riccardo Conti, Anna Widera, Malte Spiekermann, Daniel Wehner, Hansjörg Grützmacher, Leonhard Möckl

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引用次数: 0

摘要

由于细胞具有多方面的生物特性，而化学制剂的反应性又很强，因此在复杂的细胞群中精确地清除细胞受到了阻碍。目前的化学平台往往受限于其复杂性、毒性和较差的物理/化学特性。在这里，我们报告了一个结构多变的化学可调双酰膦氧化物（BAPOs）库的合成过程，它利用了光传递的时空精确性，从而建立了一种在体外和体内按需精确消融细胞的通用策略。

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Tailored Bisacylphosphane Oxides for Precise Induction of Oxidative Stress-Mediated Cell Death in Biological Systems.

Precise cell elimination within intricate cellular populations is hampered by issues arising from the multifaceted biological properties of cells and the expansive reactivity of chemical agents. Current chemical platforms are often limited by their complexity, toxicity, and poor physical/chemical properties. Here, we report on the synthesis of a structurally versatile library of chemically tunable bisacylphosphane oxides (BAPOs), which harnesses the spatiotemporal precision of light delivery, thereby establishing a universal strategy for on-demand, precise cellular ablation in vitro and in vivo.

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来源期刊

ACS Chemical Biology 生物-生化与分子生物学

CiteScore

7.50

自引率

5.00%

发文量

353

审稿时长

3.3 months

期刊介绍： ACS Chemical Biology provides an international forum for the rapid communication of research that broadly embraces the interface between chemistry and biology. The journal also serves as a forum to facilitate the communication between biologists and chemists that will translate into new research opportunities and discoveries. Results will be published in which molecular reasoning has been used to probe questions through in vitro investigations, cell biological methods, or organismic studies. We welcome mechanistic studies on proteins, nucleic acids, sugars, lipids, and nonbiological polymers. The journal serves a large scientific community, exploring cellular function from both chemical and biological perspectives. It is understood that submitted work is based upon original results and has not been published previously.