Zhaoguo Hong, Liangliang Zhang, Hong Liang and Fu-Ping Huang
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引用次数: 0
摘要
自 Bu 和 Shi 小组于 2016 年提出金属离子刺激介导的化学动力学疗法这一概念以来,人们越来越关注如何制造高效、安全和稳定的 Fenton/Fenton 类催化剂,以推进临床转化。其中,具有固有金属催化中心的金属基复合物作为传统 CDT 药剂的潜在替代品/复合物受到广泛关注。其中,铜基复合物具有优异的氧化还原特性、广泛的适应性和丰富的可获得性,使其能够在 CDT 中通过类似芬顿的反应高效生成 ROS,从而对癌细胞中的脂质、蛋白质和 DNA 造成氧化损伤。在这篇简短的综述中,我们总结了各种离散铜基金属复合物的最新进展,这些复合物旨在增强 CDT 的疗效以及在联合治疗中的应用。我们希望这篇综述能引起人们对金属复合物在推进更准确、更高效的化学动力学治疗方面的积极关注,并鼓励进一步深入研究,以促进临床转化。
Recent advances in discrete Cu complexes for enhanced chemodynamic therapy
Since the concept of metal ion stimulation-mediated chemodynamic therapy was proposed by Bu and Shi's group in 2016, increasing attention has been directed toward the fabrication of efficient, safe and stable Fenton/Fenton-like catalysts to advance clinical translation. In particular, metal-based complexes with inherent metal catalytic centers have received extensive attention as potential alternatives/complements for traditional CDT agents. Among them, copper-based complexes, which possess excellent redox properties, extensive adaptability and abundant availability, enable the efficient generation of ROS through Fenton-like reactions in CDT, thereby causing oxidative damage to lipids, proteins, and DNA in cancer cells. In this brief review, we summarize the recent progress on various discrete copper-based metal complexes aimed at enhancing the therapeutic efficacy of CDT as well as their application in combination therapy. We hope that this review will attract active attention toward metal complexes in advancing more accurate and efficient chemodynamic therapy and encourage further in-depth research to facilitate clinical translation.
期刊介绍:
Dalton Transactions is a journal for all areas of inorganic chemistry, which encompasses the organometallic, bioinorganic and materials chemistry of the elements, with applications including synthesis, catalysis, energy conversion/storage, electrical devices and medicine. Dalton Transactions welcomes high-quality, original submissions in all of these areas and more, where the advancement of knowledge in inorganic chemistry is significant.