设计用于成像氧化还原活性过渡金属信号的小分子和大分子传感器

IF 6.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Aidan T. Pezacki , Jiaying Gao , Christopher J. Chang
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引用次数: 0

摘要

过渡金属在生物学中发挥着至关重要的作用,这些营养物质作为活性位点辅助因子或通过金属变质作用调节蛋白质的活性。相反,过渡金属平衡失调会导致与衰老和疾病相关的独特的金属依赖性信号通路,如杯突症和铁突症分别导致铜和铁依赖性细胞死亡,或杯增生和铁增生分别导致铜和铁依赖性细胞生长和增殖。采用新方法检测具有金属和氧化态特异性的生物可利用过渡金属池,有助于破解它们对健康和疾病的影响。在此,我们总结了设计过渡金属成像传感器的最新进展及其在揭示新金属生物学方面的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Designing small-molecule and macromolecule sensors for imaging redox-active transition metal signaling
Transition metals play essential roles in biology, where these nutrients regulate protein activity as active site cofactors or via metalloallostery. In contrast, dysregulation of transition metal homeostasis can lead to unique metal-dependent signaling pathways connected to aging and disease, such as cuproptosis and ferroptosis for copper- and iron-dependent cell death or cuproplasia and ferroplasia for copper- and iron-dependent cell growth and proliferation, respectively. New methods that enable detection of bioavailable transition metal pools with both metal and oxidation state specificity can help decipher their contributions to health and disease. Here we summarize recent advances in designing sensors for imaging transition metals and their applications to uncover new metal biology.
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来源期刊
Current Opinion in Chemical Biology
Current Opinion in Chemical Biology 生物-生化与分子生物学
CiteScore
13.30
自引率
1.30%
发文量
113
审稿时长
74 days
期刊介绍: COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.
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