重复性经颅磁刺激作为持续性姿势感知性头晕的附加疗法

IF 2 Q3 NEUROSCIENCES

IBRO Neuroscience Reports Pub Date : 2024-10-29 DOI:10.1016/j.ibneur.2024.10.005

Yao Jia , Hongbin Wang , Dan Li , Xingli Wu , Jiawen Yang , Weifei Min , Ting Ma , He Huang , Rui Li

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引用次数: 0

摘要

背景本研究旨在评估重复经颅磁刺激（rTMS）作为持续性姿势知觉性头晕（PPPD）患者的附加疗法的临床疗效。方法在商洛市中心医院进行的这项随机对照双盲试验中，纳入了在神经内科确诊的 PPPD 患者。试验采用随机分组法，将患者按 1:1 的比例随机分为经颅磁刺激治疗组和对照组。两组患者均接受常规治疗，经颅磁刺激治疗组每天接受经颅磁刺激治疗，而对照组则按照相同的时间表接受假经颅磁刺激治疗。治疗效果主要通过眩晕障碍量表（DHI）、汉密尔顿焦虑评定量表（HAMA）和汉密尔顿抑郁评定量表（HAMD）进行评估，分别测量基线、两周后和四周结束时的眩晕、焦虑和抑郁症状。最终，2人因个人原因退出，42名参与者的数据被纳入结果分析。治疗 4 周后，经颅磁刺激治疗组的 HAMA、HAMD 和 DHI 评分明显低于对照组（p<0.05）。DHI评分与HAMA或HAMD评分之间也呈正相关。结论这项试验性研究表明，经颅磁刺激疗法是一种有益于PPPD患者的附加疗法。

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Repetitive transcranial magnetic stimulation as add-on the rapyin persistent postural-perceptual dizziness

Background

This study aims to evaluate the clinical effectiveness of repetitive transcranial magnetic stimulation (rTMS) when used as an add-on therapy for individuals with persistent postural-perceptual dizziness (PPPD).

Methods

In this randomized controlled, double-blind trial conducted at Shangluo Central Hospital, patients with PPPD diagnosed in the neurology departments were included. Participants were randomized into a rTMS treatment group and a control group in a 1:1 ratio by the randomized grouping method. Patients in both groups received conventional treatment, with the rTMS treatment group underwent daily rTMS sessions, whereas the control group received sham rTMS treatments following the same schedule. The effectiveness of the treatments was primarily assessed using the Dizziness Handicap Inventory (DHI), Hamilton Anxiety Rating Scale (HAMA), and Hamilton Depression Rating Scale (HAMD), which measured symptoms of vertigo, anxiety, and depression at baseline, after two weeks, and at the end of four weeks.

Findings

Of the 46 participants recruited, 2 were excluded due to contraindications, 22 were randomly assigned to the rTMS treatment group, and 22 were assigned to the control group. Ultimately, 2 withdrew for personal reasons, and data from 42 participants were included in the outcome analysis. HAMA, HAMD and DHI scores were significantly lower in the rTMS treatment group than in the control group after 4 weeks of treatment (p<0.05). A positive correlation was also observed between DHI scores and HAMA or HAMD scores.