薰衣草对白色念珠菌、变异链球菌、金黄色葡萄球菌的抗菌作用以及对义齿基托树脂的抗粘附作用

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2024-11-01 DOI:10.1016/j.jobcr.2024.10.014

Anitha Kuttae Viswanathan , Rajkumar Krishnan

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引用次数: 0

摘要

研究目的：确定薰衣草（真薰衣草提取物）对白色念珠菌、变异链球菌和金黄色葡萄球菌病原体的抗菌效果。将不同比例的萃取物加入聚甲基丙烯酸甲酯（PMMA）义齿基底树脂中，研究了其抗粘连效果。色谱分析和计算分子对接分析了其植物成分与潜在目标配体的结合。进行了抗菌敏感性、最小抑菌浓度、最小杀菌和杀真菌剂量以及体外细胞毒性测试。将不同比例的 LA 提取物（0、.5、1.0、1.5 和 2.0 %）添加到 PMMA 树脂中，以评估抗粘附性。结果报告显示，与对照组药物相比，LA 提取物对测试病原体具有显著的抗菌敏感性（P > 0.05）。最低浓度为 0.02 毫克的薰衣草提取物可抑制微生物生长，但细胞毒性较低（P< 0.05）。结论在义齿基底树脂中加入薰衣草提取物具有良好的抗菌特性。这项调查鼓励人们进一步研究薰衣草提取物对增强型牙科树脂的机械和物理特性的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Antimicrobial role of Lavandula angustifolia towards Candida albicans, Streptococcus mutans, Staphylococcus aureus and anti-adherence effect on denture base resin

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Antimicrobial role of Lavandula angustifolia towards Candida albicans, Streptococcus mutans, Staphylococcus aureus and anti-adherence effect on denture base resin

Objectives

The objective of the study was to determine the antimicrobial efficacy of Lavandula angustifolia (True Lavender extract) towards Candida albicans, Streptococcus mutans, Staphylococcus aureus pathogens. Varying proportions of the extract was incorporated into polymethyl methacrylate (PMMA) denture base resin and the anti-adherent effect was investigated.

Methods

An in-vitro study was performed after pure extract was obtained from Lavandula angustifolia (LA) flowers using a solvent based hot extraction process. Chromatographic analysis and computational molecular docking were done to analyze its phytoconstituents with potential target-ligand bond. Tests of antimicrobial susceptibility, minimum inhibitory concentration, minimum bactericidal and fungicidal dosages and in-vitro cytotoxicity were performed. Different proportions of LA extract (0, .5, 1.0, 1.5, and 2.0 %) were added to PMMA resin to assess anti-adherence property. Obtained data were statistically analyzed with One-way ANOVA followed by Tukey post-hoc tests.

Results

The reports revealed significant antimicrobial susceptibility against the test pathogens compared to control drugs (P > 0.05). A minimum concentration of .02 mg of lavender extract inhibited microbial growth with low cytotoxicity (P < 0.05). The highest anti-adherent activity was observed in the .5 % LA-incorporated PMMA resin group (P = 0.0001).

Conclusions

Incorporating lavender extract into denture base resin demonstrated promising antimicrobial properties. This investigation encourages further research to understand its effects on mechanical and physical properties of reinforced dental resins.

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.