与药物使用障碍复发相关的基因组因素：重要综述

Q1 Psychology

Addictive Behaviors Reports Pub Date : 2024-10-30 DOI:10.1016/j.abrep.2024.100569

Noora Al-Marzooqi , Hanan Al-Suhail , Mohammad O. AlRefai , Hamid A Alhaj

{"title":"与药物使用障碍复发相关的基因组因素：重要综述","authors":"Noora Al-Marzooqi , Hanan Al-Suhail , Mohammad O. AlRefai , Hamid A Alhaj","doi":"10.1016/j.abrep.2024.100569","DOIUrl":null,"url":null,"abstract":"<div><div>Several genetic and epigenetic factors contribute to the elevated substance use disorder (SUD) relapse vulnerability, yet a comprehensive investigation into these factors is lacking. This review aims to delve into current literature to highlight key genomic factors associated with SUD relapse.</div><div>Focusing on genetic predisposition and epigenetic modifications the review synthesized research findings of several genetic polymorphisms, histone modifications and DNA methylation patterns contributing to the initiation of SUD and the elevated relapse susceptibility. Notably, specific gene polymorphisms, such as Dopamine Receptor D2 gene (DRD2), Gamma-Aminobutyric Acid Receptor Alpha gene (GABRA2), Catechol-O-methyltransferase (COMT) gene, Dopamine Transporter (DAT1) gene and others were identified to be connected to various patterns of SUD relapse. Furthermore, SUD initiation and relapse has been shown to be influenced by epigenetics. Specifically, CpG hypermethylation has been associated with severe alcohol use disorder in the 5′ untranslated region of the Bladder Cancer Associated Protein gene (BLCAP) and the upstream region of the Active BCR Related gene (ABR). Co-users of cannabis and tobacco showed notable variations in CpG site methylation, especially at the Aryl Hydrocarbon Receptor Repressor (AHRR), and factor II receptor-like 3 gene sites (F2RL3).</div><div>In conclusion, there is good evidence of certain associations between genomic factors and relapse to SUD. However, further research is needed to ascertain causality effects of these factors and develop novel interventions for effective treatment and relapse prevention.</div></div>","PeriodicalId":38040,"journal":{"name":"Addictive Behaviors Reports","volume":"20 ","pages":"Article 100569"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Genomic factors associated with substance use disorder relapse: A critical review\",\"authors\":\"Noora Al-Marzooqi , Hanan Al-Suhail , Mohammad O. AlRefai , Hamid A Alhaj\",\"doi\":\"10.1016/j.abrep.2024.100569\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Several genetic and epigenetic factors contribute to the elevated substance use disorder (SUD) relapse vulnerability, yet a comprehensive investigation into these factors is lacking. This review aims to delve into current literature to highlight key genomic factors associated with SUD relapse.</div><div>Focusing on genetic predisposition and epigenetic modifications the review synthesized research findings of several genetic polymorphisms, histone modifications and DNA methylation patterns contributing to the initiation of SUD and the elevated relapse susceptibility. Notably, specific gene polymorphisms, such as Dopamine Receptor D2 gene (DRD2), Gamma-Aminobutyric Acid Receptor Alpha gene (GABRA2), Catechol-O-methyltransferase (COMT) gene, Dopamine Transporter (DAT1) gene and others were identified to be connected to various patterns of SUD relapse. Furthermore, SUD initiation and relapse has been shown to be influenced by epigenetics. Specifically, CpG hypermethylation has been associated with severe alcohol use disorder in the 5′ untranslated region of the Bladder Cancer Associated Protein gene (BLCAP) and the upstream region of the Active BCR Related gene (ABR). Co-users of cannabis and tobacco showed notable variations in CpG site methylation, especially at the Aryl Hydrocarbon Receptor Repressor (AHRR), and factor II receptor-like 3 gene sites (F2RL3).</div><div>In conclusion, there is good evidence of certain associations between genomic factors and relapse to SUD. However, further research is needed to ascertain causality effects of these factors and develop novel interventions for effective treatment and relapse prevention.</div></div>\",\"PeriodicalId\":38040,\"journal\":{\"name\":\"Addictive Behaviors Reports\",\"volume\":\"20 \",\"pages\":\"Article 100569\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Addictive Behaviors Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352853224000464\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Psychology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Addictive Behaviors Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352853224000464","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Psychology","Score":null,"Total":0}

引用次数: 0

摘要

多种遗传和表观遗传因素导致药物使用障碍（SUD）复发率升高，但目前还缺乏对这些因素的全面调查。本综述旨在深入研究当前的文献，以突出与药物滥用症复发相关的关键基因组因素。本综述以遗传易感性和表观遗传修饰为重点，综合了几种基因多态性、组蛋白修饰和 DNA 甲基化模式的研究结果，这些基因多态性、组蛋白修饰和 DNA 甲基化模式是导致药物滥用症发病和复发易感性升高的原因。值得注意的是，多巴胺受体 D2 基因 (DRD2)、γ-氨基丁酸受体 Alpha 基因 (GABRA2)、儿茶酚-O-甲基转移酶 (COMT) 基因、多巴胺转运体 (DAT1) 基因等特定基因的多态性被确认与各种 SUD 复发模式有关。此外，事实证明，药物依赖性成瘾的诱发和复发受表观遗传学的影响。具体来说，在膀胱癌相关蛋白基因（BLCAP）的 5′非翻译区和活性 BCR 相关基因（ABR）的上游区域，CpG 高甲基化与严重酗酒症有关。大麻和烟草的共同使用者在 CpG 位点甲基化方面表现出明显的差异，尤其是在芳香烃受体抑制因子（AHRR）和因子 II 受体样 3 基因位点（F2RL3）。总之，有充分证据表明基因组因素与药物滥用的复发之间存在某些关联，但还需要进一步研究，以确定这些因素的因果关系，并开发新的干预措施，从而有效治疗和预防复发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Genomic factors associated with substance use disorder relapse: A critical review

Several genetic and epigenetic factors contribute to the elevated substance use disorder (SUD) relapse vulnerability, yet a comprehensive investigation into these factors is lacking. This review aims to delve into current literature to highlight key genomic factors associated with SUD relapse.

Focusing on genetic predisposition and epigenetic modifications the review synthesized research findings of several genetic polymorphisms, histone modifications and DNA methylation patterns contributing to the initiation of SUD and the elevated relapse susceptibility. Notably, specific gene polymorphisms, such as Dopamine Receptor D2 gene (DRD2), Gamma-Aminobutyric Acid Receptor Alpha gene (GABRA2), Catechol-O-methyltransferase (COMT) gene, Dopamine Transporter (DAT1) gene and others were identified to be connected to various patterns of SUD relapse. Furthermore, SUD initiation and relapse has been shown to be influenced by epigenetics. Specifically, CpG hypermethylation has been associated with severe alcohol use disorder in the 5′ untranslated region of the Bladder Cancer Associated Protein gene (BLCAP) and the upstream region of the Active BCR Related gene (ABR). Co-users of cannabis and tobacco showed notable variations in CpG site methylation, especially at the Aryl Hydrocarbon Receptor Repressor (AHRR), and factor II receptor-like 3 gene sites (F2RL3).

In conclusion, there is good evidence of certain associations between genomic factors and relapse to SUD. However, further research is needed to ascertain causality effects of these factors and develop novel interventions for effective treatment and relapse prevention.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Addictive Behaviors Reports Medicine-Psychiatry and Mental Health

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Addictive Behaviors Reports is an open-access and peer reviewed online-only journal offering an interdisciplinary forum for the publication of research in addictive behaviors. The journal accepts submissions that are scientifically sound on all forms of addictive behavior (alcohol, drugs, gambling, Internet, nicotine and technology) with a primary focus on behavioral and psychosocial research. The emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. We are particularly interested in ''non-traditional'', innovative and empirically oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research. Studies that might encourage new lines of inquiry as well as scholarly commentaries on topical issues, systematic reviews, and mini reviews are also very much encouraged. We also welcome multimedia submissions that incorporate video or audio components to better display methodology or findings.