{"title":"在一例对激素敏感的转移性前列腺癌患者中，姑息放疗导致了严重的中性粒细胞减少症。","authors":"Fumisato Maesaka, Atsushi Tomioka, Chie Matsushita, Noriko Horikawa, Kiyohide Fujimoto","doi":"10.1002/iju5.12783","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Radiotherapy for widespread bone metastasis results in severe hematological toxicity.</p>\n </section>\n \n <section>\n \n <h3> Case presentation</h3>\n \n <p>A 71-year-old male was diagnosed with metastatic hormone-sensitive prostate cancer (cT4N1M1b) and treated with apalutamide and degarelix. Concurrently, palliative radiation therapy was sequentially initiated for the 1st, 5th, and 10th thoracic vertebrae and right femur. On day 35 after treatment, severe neutropenia necessitated treatment interruption and required 23 days for neutrophil recovery with a granulocyte colony-stimulating factor agent.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Owing to the severe hematologic toxicity caused by extensive radiation therapy for multiple bone lesions, treatment prioritization by lesion and avoiding irradiation of the red bone marrow is essential.</p>\n </section>\n </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"7 6","pages":"480-483"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531869/pdf/","citationCount":"0","resultStr":"{\"title\":\"Severe neutropenia caused by palliative radiation therapy in a case of metastatic hormone-sensitive prostate cancer\",\"authors\":\"Fumisato Maesaka, Atsushi Tomioka, Chie Matsushita, Noriko Horikawa, Kiyohide Fujimoto\",\"doi\":\"10.1002/iju5.12783\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>Radiotherapy for widespread bone metastasis results in severe hematological toxicity.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Case presentation</h3>\\n \\n <p>A 71-year-old male was diagnosed with metastatic hormone-sensitive prostate cancer (cT4N1M1b) and treated with apalutamide and degarelix. Concurrently, palliative radiation therapy was sequentially initiated for the 1st, 5th, and 10th thoracic vertebrae and right femur. On day 35 after treatment, severe neutropenia necessitated treatment interruption and required 23 days for neutrophil recovery with a granulocyte colony-stimulating factor agent.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Owing to the severe hematologic toxicity caused by extensive radiation therapy for multiple bone lesions, treatment prioritization by lesion and avoiding irradiation of the red bone marrow is essential.</p>\\n </section>\\n </div>\",\"PeriodicalId\":52909,\"journal\":{\"name\":\"IJU Case Reports\",\"volume\":\"7 6\",\"pages\":\"480-483\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531869/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IJU Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/iju5.12783\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IJU Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/iju5.12783","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Severe neutropenia caused by palliative radiation therapy in a case of metastatic hormone-sensitive prostate cancer
Introduction
Radiotherapy for widespread bone metastasis results in severe hematological toxicity.
Case presentation
A 71-year-old male was diagnosed with metastatic hormone-sensitive prostate cancer (cT4N1M1b) and treated with apalutamide and degarelix. Concurrently, palliative radiation therapy was sequentially initiated for the 1st, 5th, and 10th thoracic vertebrae and right femur. On day 35 after treatment, severe neutropenia necessitated treatment interruption and required 23 days for neutrophil recovery with a granulocyte colony-stimulating factor agent.
Conclusion
Owing to the severe hematologic toxicity caused by extensive radiation therapy for multiple bone lesions, treatment prioritization by lesion and avoiding irradiation of the red bone marrow is essential.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
