以淋巴细胞和浆细胞浸润为主的输尿管间质性肾炎并发放射性肾病一例

IF 1.1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-06-01 Epub Date: 2024-11-01 DOI:10.2169/internalmedicine.4265-24

Tatsuaki Kosaka, Koji Takaori, Azusa Izumiya, Daisuke Hirai, Mitsuteru Koizumi, Shinya Yamamoto, Akiko Mii, Akira Shimizu, Kiyonao Nakamura, Norio Araki, Koichi Seta

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引用次数: 0

摘要

一名 64 岁的日本妇女出现严重血尿，被诊断为 IVB 期宫颈癌。化疗后出现肾功能障碍，肾活检发现肾血栓性微血管病（TMA）和肾小管间质性肾炎（TIN），这是放射性肾病的非典型特征。对比度增强计算机断层扫描显示出楔形的高对比度区域，与肾脏中的高辐射剂量区域一致，因此被诊断为放射性肾病。本病例强调了综合临床、病理和放射学结果诊断放射性肾病、非典型肾活检结果以及 TIN 和肾 TMA 合并症的重要性。

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查看原文本刊更多论文

Radiation Nephropathy Complicated by Tubulointerstitial Nephritis with Predominantly Lymphocyte and Plasma Cell Infiltration.

A 64-year-old Japanese woman presented with gross hematuria and was diagnosed with stage IVB cervical cancer. Renal dysfunction was observed following chemoradiation therapy, and a renal biopsy revealed renal thrombotic microangiopathy (TMA) and tubulointerstitial nephritis (TIN), which are atypical features of radiation nephropathy. Contrast-enhanced computed tomography revealed wedge-shaped areas of high contrast, consistent with areas of high radiation dose in the kidneys, thus leading to the diagnosis of radiation nephropathy. This case underscores the importance of integrating clinical, pathological, and radiological findings for the diagnosis of radiation nephropathy, atypical renal biopsy findings, and a combination of TIN and renal TMA.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.