在治疗阿尔茨海默病时，请牢记神经炎症：小胶质细胞视角

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2024-11-03 DOI:10.1177/13872877241290693

Stefania Gessi, Prisco Mirandola, Stefania Merighi

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引用次数: 0

摘要

这篇评论详细分析了最新发表的一篇论文，该论文涉及淀粉样蛋白-β（Aβ）聚集的小分子诱饵对小胶质细胞活化的影响。研究发现，NSC16224诱饵肽能抑制小胶质细胞在Aβ40和Aβ42处理后释放促炎细胞因子TNFα和IL6。这项研究探讨了阻断导致阿尔茨海默病（AD）进展的一系列事件的可能性。在这里，我们将讨论这些结果在神经炎症中的意义，并强调诱饵肽对研究和开发治疗阿尔茨海默病新药的更大意义。

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Keep neuroinflammation in mind when addressing Alzheimer's disease: A microglia perspective.

This commentary offers a detailed examination of a newly published paper on the effects of small molecule decoys of amyloid-β (Aβ) aggregation on microglial activation. It was discovered that the NSC16224 decoy peptide inhibited proinflammatory cytokines TNFα and IL6 release from microglia in response to Aβ₄₀ and Aβ₄₂ treatment. The research addresses the potential of blocking a sequence of events that lead to the progression of Alzheimer's disease (AD). Here, we discuss the significance of these results in neuroinflammation, highlighting the greater implications for how decoy peptides would be interesting for the research and development of new drugs for AD therapy.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.