蓝光反射成像在非灌注区检测中的应用:多模态分析的启示。

IF 1.9 Q2 OPHTHALMOLOGY
Ricardo Leitão Guerra, Gabriel Castilho Sandoval Barbosa, Cezar Leitão Guerra, Emmerson Badaro, Luiz Roisman, Luiz Filipe Lucatto, Eduardo Novais
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引用次数: 0

摘要

设计研究对象: 根据现有的综合影像学数据选取五例病例:方法:本研究对五个病例的图像进行回顾性分析,重点分析视网膜单色蓝光反射率的使用情况:本研究对五个病例的图像进行了回顾性分析,重点是利用视网膜单色蓝光反射(BLR)成像检测非灌注区。两例镰状细胞视网膜病变病例通过宽视野荧光素血管造影术发现了周边视网膜非灌注区。另外三例病例--一例视网膜分支静脉闭塞,一例视网膜分支动脉闭塞,一例伴有旁中心急性中间黄斑病变,通过结构性 OCT 和 OCTA 发现了局灶性黄斑无灌注。经荧光素血管造影、OCT 和 OCTA 确认的无灌注视网膜组织区域随后与 BLR 图像的结果相关联。这种关联旨在确定这些成像模式之间的任何潜在关联:加强对利用视网膜单色 BLR 图像作为非灌注生物标志物的理解:结果:荧光素血管造影确定的灌注缺陷与 BLR 图像中观察到的低反射区域存在定性相关性。OCTA 深部毛细血管丛检查结果与 BLR 图像之间也存在显著的相关性。此外,在结构性 OCT 厚度图上发现的视网膜变薄区域与 BLR 图像中的低反射区域相对应。这表明 BLR 在识别非灌注视网膜区域方面具有潜力:这项研究通过 OCT、OCTA 和血管造影术的相关性进一步证明,BLR 可以以非侵入性的方式有效识别视网膜非灌注区域。还需要进一步的研究来评估该方法的灵敏度、特异性和局限性。虽然蓝光与视网膜的相互作用导致镜面反射和散射的现象已经得到证实,但这项研究是一项开创性的工作,它提出了这一现象可能与哪些特定视网膜结构有关。这一新颖见解为深入探索利用蓝光成像技术评估视网膜血管异常的潜在机制和临床应用开辟了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Blue light reflectance imaging in non-perfusion areas detection: insights from multimodal analysis.

Design: A retrospective, cross-sectional image analysis using a convenience sample.

Subjects: Five cases selected based on the availability of comprehensive imaging data.

Methods: This study involved a retrospective review of images from five cases, focusing on the use of retinal monochromatic blue light reflectance (BLR) imaging to detect non-perfusion areas. Two cases of sickle-cell retinopathy demonstrated peripheral retinal non-perfusion identified through widefield fluorescein angiography. Three other cases-one with branch retinal vein occlusion, one with branch retinal artery occlusion, and one presenting paracentral acute middle maculopathy showed focal macular non-perfusion detected by structural OCT and OCTA. The areas of nonperfused retinal tissue, confirmed by fluorescein angiography, OCT, and OCTA, were then correlated with findings from the BLR image. This correlation aimed to identify any potential associations between these imaging modalities.

Main outcome measures: Enhance understanding of the utilization of retinal monochromatic BLR images as a non-perfusion biomarker.

Results: The perfusion defects identified through fluorescein angiography were qualitatively correlated with hypo-reflective regions observed in the BLR images. A notable correlation was also observed between the OCTA deep capillary plexus findings and the BLR images. Additionally, areas of retinal thinning identified on structural OCT thickness maps corresponded with the hypo-reflective regions in the BLR images. This indicates the potential of BLR in identifying non-perfused retinal areas.

Conclusions: This study reinforces the evidence, through OCT, OCTA, and angiographic correlation, that the BLR can effectively identify areas of retinal non-perfusion in a non-invasive manner. Further research is warranted to assess the method's sensitivity, specificity, and limitations. While the interaction of blue light with the retina, leading to specular reflections and scattering, is established, this research represents a pioneering effort in suggesting which specific retinal structures may be implicated in this phenomenon. This novel insight opens avenues for deeper exploration into the underlying mechanisms and potential clinical applications of utilizing the BLR imaging technique for assessing retinal vascular abnormalities.

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来源期刊
CiteScore
3.50
自引率
4.30%
发文量
81
审稿时长
19 weeks
期刊介绍: International Journal of Retina and Vitreous focuses on the ophthalmic subspecialty of vitreoretinal disorders. The journal presents original articles on new approaches to diagnosis, outcomes of clinical trials, innovations in pharmacological therapy and surgical techniques, as well as basic science advances that impact clinical practice. Topical areas include, but are not limited to: -Imaging of the retina, choroid and vitreous -Innovations in optical coherence tomography (OCT) -Small-gauge vitrectomy, retinal detachment, chromovitrectomy -Electroretinography (ERG), microperimetry, other functional tests -Intraocular tumors -Retinal pharmacotherapy & drug delivery -Diabetic retinopathy & other vascular diseases -Age-related macular degeneration (AMD) & other macular entities
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