幽门螺杆菌感染与非酒精性脂肪肝无关:一项为期两年的队列研究

IF 2 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Huabo Zheng, Tangmeng Guo, Xiaofang Zhao, Kun Wang, Shengshuai Shan, Songpu Xie, Yichen Xu, Chengyun Liu, Weilin Lu
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引用次数: 0

摘要

导言:以前的研究对幽门螺杆菌感染与非酒精性脂肪肝(NAFLD)之间的关系报道不一:以往的研究对幽门螺杆菌(H. pylori)感染与非酒精性脂肪肝(NAFLD)之间关系的研究结果并不一致:方法:对2063名基线无非酒精性脂肪肝的成年人进行了一项队列研究,这些人参加了包括13C尿素呼气试验和腹部超声波检查在内的重复健康检查,以评估幽门螺杆菌感染与非酒精性脂肪肝发展之间的联系:结果:在平均 1.7 年的随访期间,我们未发现幽门螺杆菌感染与非酒精性脂肪肝之间存在显著关联(危险比 (HR) = 1.10 (0.86, 1.40), p = 0.4689)。我们还发现,较高的年龄、体重指数(BMI)、收缩压、舒张压、空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)是非酒精性脂肪肝发生的危险因素,而高密度脂蛋白胆固醇(HDL-C)是非酒精性脂肪肝发生的保护因素:结论:幽门螺杆菌感染与非酒精性脂肪肝的发生可能没有正相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Helicobacter pylori Infection Is Not Associated with Nonalcoholic Fatty Liver Disease: A Two-Year Cohort Study.

Introduction: Previous studies reported inconsistent results of the association between Helicobacter pylori infection and nonalcoholic fatty liver disease (NAFLD).

Methods: A cohort study of 2,063 adults without NAFLD at baseline, who participated in a repeated health checkup including a 13C-urea breath test and abdominal ultrasonography, was conducted to evaluate the link between H. pylori infection and NAFLD development.

Results: During a mean follow-up period of 1.7 years, we did not find a significant association between H. pylori infection and NAFLD (hazard ratio = 1.10 (0.86, 1.40), p = 0.4689). We also found that higher age, body mass index (BMI), systolic blood pressure (systolic BP), diastolic blood pressure (diastolic BP), fasting blood glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were risk factors, and high-density lipoprotein cholesterol (HDL-C) was a protective factor for NAFLD development.

Conclusion: H. pylori infection might not be positively related to NAFLD development.

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来源期刊
Digestive Diseases
Digestive Diseases 医学-胃肠肝病学
CiteScore
4.80
自引率
0.00%
发文量
58
审稿时长
2 months
期刊介绍: Each issue of this journal is dedicated to a special topic of current interest, covering both clinical and basic science topics in gastrointestinal function and disorders. The contents of each issue are comprehensive and reflect the state of the art, featuring editorials, reviews, mini reviews and original papers. These individual contributions encompass a variety of disciplines including all fields of gastroenterology. ''Digestive Diseases'' bridges the communication gap between advances made in the academic setting and their application in patient care. The journal is a valuable service for clinicians, specialists and physicians-in-training.
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