无外加电解质电化学一锅级联合成硫（硒）氰基取代的噻唑烷-2-亚胺。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-10-30 DOI:10.1039/D4OB01626B

Xiao Yu, Liqiang Hao, Xian Liu, Shengkui Jin, Yangchen Li, Yiping Liu and Yafei Ji

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引用次数: 0

摘要

我们开发了一种新的合成方法，通过电化学单锅级联反应生成硫（硒）氰基取代的噻唑烷-2-亚胺。该反应采用异硫氰酸酯、N-2-烯-1-胺和 KSCN（或 KSeCN），条件温和，无需金属、化学氧化剂和外部电解质。该方法对未活化的烯类有效，并有助于合成五元和六元硫（硒）氰基取代的噻唑烷-2-亚胺。该方法操作简便，可扩大到克级生产规模，突出了其广泛应用的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Electrochemical one-pot cascade synthesis of thio(seleno)cyanato-substituted thiazolidine-2-imines without external electrolyte†

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Electrochemical one-pot cascade synthesis of thio(seleno)cyanato-substituted thiazolidine-2-imines without external electrolyte†

A novel synthetic method has been developed for generating thio(seleno)cyanato-substituted thiazolidine-2-imines via an electrochemical one-pot cascade reaction. This reaction employs isothiocyanates, N-2-en-1-amines, and KSCN (or KSeCN) under mild conditions, obviating the need for metals, chemical oxidants, and external electrolytes. The protocol is effective with unactivated alkenes and facilitates the synthesis of five- and six-membered thio(seleno)cyanato-substituted thiazolidine-2-imines. The versatility is demonstrated by its straightforward operation and scalability to gram-scale production, underscoring its potential for broader application.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.