影响急性白血病异基因造血干细胞移植患者第 100 天存活率的预后因素--单中心经验。

Awais Siddiq, Mehreen Ali Khan, Jehanzeb Ur Rehman, Yasir Abbas, Hashim Khan, Uzma Rahim
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引用次数: 0

摘要

研究目的确定影响接受异基因造血干细胞移植(Allo-HSCT)的急性白血病患者头100天存活率的因素:描述性研究。研究地点和时间:巴基斯坦拉瓦尔品第骨髓移植中心,2016年3月至2022年2月:纳入接受异体骨髓移植(Allo-HSCT)的完全缓解(CR)的急性髓性白血病(AML)或急性淋巴细胞白血病(ALL)患者。收集的数据包括患者人口统计学、诊断、缓解状态、移植前分析、供体相容性、调理方案、GVHD预防、移植时间、移植后并发症、死亡原因和100天的总生存率(OS):在101名移植受者(平均年龄为24±11.05岁;男性76人,女性25人)中,41人患有急性髓细胞白血病,60人患有急性淋巴细胞白血病。90名患者接受了匹配的同胞供体(MSD)-HSCT,11名患者接受了单倍体同胞供体-HSCT。13岁以下患者的存活率高于年龄较大的患者(94.4% vs. 67.5%,P = 0.03)。移植前血清铁蛋白水平过高(>2500 mg/dl)预示着较低的OS(48.9%对100%):确定可改变的因素可改善长期支持和随访,提高欠发达国家患者的治疗效果:造血干细胞移植 第100天存活率 急性白血病 巴基斯坦
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prognostic Factors Affecting Day+100 Survival in Patients Undergoing Allogeneic Haematopoietic Stem Cell Transplantation for Acute Leukaemia - A Single Centre Experience.

Objective: To determine the factors affecting the first 100 days of survival in acute leukaemia patients undergoing allogeneic haematopoietic stem cell transplantation (Allo-HSCT).

Study design: Descriptive study. Place and Duration of the Study: Bone Marrow Transplant Centre, Rawalpindi, Pakistan, from March 2016 to February 2022.

Methodology: Patients with acute myeloid leukaemia (AML) or acute lymphoblastic leukaemia (ALL) in complete remission (CR) undergoing Allo-HSCT were included. Data were collected on patient demographics, diagnosis, remission status, pre-transplant analysis, donor compatibility, conditioning regimen, GVHD prophylaxis, engraftment times, post-transplant complications, mortality causes, and overall survival (OS) at 100 days.

Results: Among 101 transplant recipients (mean age of 24 ± 11.05 years; n = 76 males, n = 25 females), 41 had AML and 60 had ALL. Ninety patients underwent matched sibling donor (MSD)-HSCT, while 11 had haplo-identical sibling-HSCT. Patients ≤13 years had higher survival rates than older patients (94.4% vs. 67.5%, p = 0.03). High pre-transplant serum ferritin levels (>2500 mg/dl) predicted lower OS (48.9% vs. 100% in ferritin <1000 mg/dl, p <0.01). AML patients had a survival advantage over ALL patients (82.9% vs. 65%, p = 0.05). Early neutrophil engraftment within 14 days correlated with better survival (96.4% vs. 54.3%, p <0.01). Lastly, severe mucositis also adversely affected survival (60% in Grade III vs. 9.5% in Grade IV, p <0.01).

Conclusion: Identifying modifiable factors can improve long-term support and follow-up, enhancing the patient outcomes in underdeveloped nations.

Key words: Haematopoietic stem cell transplant, Day + 100 survival, Acute leukaemia, Pakistan.

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