探索同时锻炼对控制 II 型糖尿病的协同作用:元分析。

Uroosa Amin, Qurat-Ul-Ain Adnan, Tauseef Ahmad, Sumaira Imran Farooqui
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引用次数: 0

摘要

从 2015 年到 2023 年 3 月,我们在谷歌学术、PubMed、Pedro、CINAHL 和 Medline 上进行了全面搜索,评估了同期运动(CE)作为一种新方法对 II 型糖尿病(T2DM)患者的疗效。研究选取了 16 项 RCT,这些研究对 T2DM 患者每周至少三天的 CE(有氧运动+阻力运动)效果进行了评估,对照组则接受常规护理或不做运动。符合条件的研究至少评估了一个血糖变量,即 HbA1C、空腹血糖水平 (FBGL) 和胰岛素抵抗静态模型评估 (HOMA-IR)。随访时间≥8 周的干预措施、任何年龄和性别的患者以及英文文献均可纳入。采用 Cochrane 协作组织的偏倚风险工具(RoB 2)进行了严格审查,以尽量减少偏倚,其中包括随机化过程、偏离预期干预、结果数据缺失、结果测量和选择偏倚。CE明显改善了HbA1C(95% CI为-0.654至0.363,I2=84.92%,中度异质性)、FBGL(95% CI为-0.239至1.145,I2=93.74%,高度异质性)和胰岛素抵抗(HOMA-IR)(95% CI为-0.593至0.544,I2=92.85%,高度异质性)。总之,研究结果表明,作为一种干预措施,CE 有可能对 T2DM 患者的血糖控制产生积极影响。然而,相对较高的 I² 值表明各研究之间存在显著的差异,需要进一步研究探讨导致这种异质性的因素、运动方案与进展以及糖尿病持续时间,这对确定精确的剂量-反应关系更具挑战性。因此,需要进行更多的研究,以深入了解这些因素对 T2DM 管理的影响。关键字糖化血红蛋白 血糖控制 胰岛素抵抗 体育锻炼 II型糖尿病
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the Synergistic Effects of Concurrent Exercise for Managing Type-II Diabetes Mellitus: A Meta-Analysis.

The effectiveness of concurrent exercise (CE) as an emerging approach for type-II diabetes mellitus (T2DM) patients was evaluated through a comprehensive search on Google Scholar, PubMed, Pedro, CINAHL, and Medline from 2015 to March 2023. Sixteen RCTs were selected which evaluated CE (aerobic + resistance in the same session) effects on a minimum of three days/week among T2DM patients, and the control group received usual care or no exercise. Studies that evaluated at least one glycaemic variable, i.e. HbA1C, fasting blood glucose level (FBGL), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), were eligible. Intervention with a follow-up period of ≥8 weeks, patients of any age and gender, and literature in the English language were included. A rigorous review was performed using the Cochrane Collaboration risk of bias tool (RoB 2) to minimise biases, which include the randomisation process, deviation from intended intervention, missing outcome data, outcome measurement, and selection bias. CE significantly improved HbA1C (95% CI of -0.654 to 0.363, I2 = 84.92% moderate heterogeneity), FBGL (95% CI of -0.239 to 1.145, I2 = 93.74% - high level of heterogeneity), and insulin resistance (HOMA-IR) (95% CI of -0.593 to 0.544, I2 = 92.85% - high level of heterogeneity). Collectively, findings indicate the potential of CE as an intervention to impact glycaemic control in T2DM patients positively. However, the relatively high I² values suggest notable variability among studies, and further research to explore the factors contributing to this heterogeneity, exercise protocol along with progression, and duration of diabetes are needed, which is more challenging to determine a precise dose-response relationship. Therefore, more studies are required to provide thorough insights into these components for T2DM management. Key Words: Glycated haemoglobin, Glycaemic control, Insulin resistance, Physical exercise, Type-II diabetes mellitus.

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