当过敏症没有名字时:特发性过敏性休克是由辅助因子引起的吗?

IF 3.3 Q2 ALLERGY
Frontiers in allergy Pub Date : 2024-10-18 eCollection Date: 2024-01-01 DOI:10.3389/falgy.2024.1468945
Shuayb Elkhalifa, Haggar Elbashir, Mohamed Abuzakouk
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引用次数: 0

摘要

特发性过敏性休克(IA)是一种严重的过敏反应,没有可识别的外部诱因,给诊断和管理带来了巨大挑战。然而,越来越多的证据表明,许多被归类为特发性的病例实际上可能是由运动、激素波动、药物或隐藏的过敏原等辅助因素引起的。这篇微型综述探讨了对特发性过敏反应不断发展的认识,强调了这些辅助因素在引发或扩大过敏反应中的作用。它强调了诊断工具(包括成分分辨诊断法)的进步如何帮助识别以前未检测到的过敏原,从而提高诊断的准确性并降低真正特发性病例的发病率。随着我们对过敏性休克及其内在机制的认识不断加深,对考虑到辅因子参与的全面评估的需求也日益明确。要改善患者的预后并更好地控制这种复杂的病情,就必须在这一领域继续开展研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
When allergies have no name: is idiopathic anaphylaxis driven by co-factors?

Idiopathic anaphylaxis (IA) is a severe allergic reaction without identifiable external triggers, presenting significant challenges in diagnosis and management. However, growing evidence suggests that many cases classified as idiopathic may actually be driven by cofactors such as exercise, hormonal fluctuations, medications, or hidden allergens. This mini-review explores the evolving understanding of IA, highlighting the role of these cofactors in triggering or amplifying anaphylactic reactions. It emphasizes how advances in diagnostic tools, including component-resolved diagnostics, are helping to identify previously undetected allergens, leading to more accurate diagnoses and reducing the prevalence of true idiopathic cases. As our knowledge of anaphylaxis and its underlying mechanisms deepens, the need for comprehensive evaluations that account for cofactor involvement becomes increasingly clear. Continued research in this area is essential to improve patient outcomes and better manage this complex condition.

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来源期刊
CiteScore
2.80
自引率
0.00%
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12 weeks
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