尼日利亚北部水产养殖中的抗生素耐药性及利用 "一体健康 "视角缓解抗生素耐药性。

IF 1.5 3区 农林科学 Q2 VETERINARY SCIENCES
Nma B Alhaji, Ismail Ayoade Odetokun, Mohammed S Jibrin, Mohammed K Lawan, Jacob Kwaga
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引用次数: 0

摘要

本研究开展了一项横断面研究,以评估 2019 年至 2020 年期间尼日利亚北部水产养殖中抗生素的使用、残留、抗药性及其产生的驱动因素。对随机抽取的 151 名养殖户进行了结构化问卷调查。采用酶联免疫吸附试验(ELISA)对鱼类、鱼柱和废水样本进行了残留检测和定量分析。我们进行了描述性和分析性统计分析。所有被选中的养殖户都参与了研究,78.1%的养殖户在池塘中使用抗生素。大多数(77.1%)养殖户不知道滥用抗生素的后果,73.3%的养殖户提到滥用和过度使用抗生素不会导致残留和抗药性。最常用的抗生素是四环素类(TCs)(99.2%)。残留和耐药性传播的主要风险途径是:摄入受污染的鱼类及其产品、直接接触受污染的鱼类和粪便以及池塘环境中受污染的水和气溶胶。影响残留和耐药性产生的重要社会和文化因素包括抗生素的滥用/过量使用(比值比 [OR] = 3.8;95% 置信区间 [CI]:1.62-8.74),以及养殖户的教育程度和专业知识不足(比值比 [OR] = 2.9;95% 置信区间 [CI]:1.24-6.94)。柱体和废水中 TCs 的平均残留量为 123.6 ± 18.2 μg/kg-1。研究发现,人们对抗生素使用的认识和态度不佳。应通过对农民的教育来促进适当的抗生素管理。已发现的社会和文化因素可通过 "一体健康 "方法加以缓解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antibiotic resistance and mitigation using One Health lens in aquaculture of Northern Nigeria.

A cross-sectional study was conducted to assess antibiotic usage, residues, resistance and drivers of their emergence in fish aquaculture in Northern Nigeria between 2019 and 2020. A structured questionnaire was administered to 151 randomly selected farmers. Fish, column and wastewater samples were analysed with enzyme link immunosorbent assay (ELISA) for residue detection and quantification. We performed descriptive and analytic statistical analyses. All selected farmers participated, 78.1% used antibiotics in ponds. Majority (77.1%) of the farmers did not know what antibiotic misuse entailed and 73.3% mentioned that antibiotic misuse and overuse cannot predispose to residues and resistance. The most frequently used antibiotics were tetracyclines (TCs) (99.2%). Significant risk routes for residue and resistance spread were: contaminated fish and its products ingestion, direct contact with fish and fomites contaminated as well as water and aerosols contaminated in the pond environment. Significant social and cultural that influenced residue and resistance development include antibiotics misuse/overuse (Odds Ratio [OR] = 3.8; 95% confidence interval [CI]: 1.62-8.74) as well as poor education and expertise of the farmers (OR = 2.9; 95% CI: 1.24-6.94). The mean TCs residues level in column and wastewater was 123.6 ± 18.2 μg/kg-1. Poor knowledge and attitudes regarding antibiotic usage were identified. Adequate antibiotic stewardship should be promoted through farmers' education. Identified social and cultural factors can be mitigated through the 'One Health' approach.

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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
13
审稿时长
16 weeks
期刊介绍: The Onderstepoort Journal of Veterinary Research, is the official publication of the Onderstepoort Veterinary Institute. While it considers submissions from any geographic region, its focus is on Africa and the infectious and parasitic diseases and disease vectors that affect livestock and wildlife on the continent.
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