尼古丁成瘾男性的功能连接变化：三重网络模型研究

IF 5.3 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry Pub Date : 2024-11-02 DOI:10.1016/j.pnpbp.2024.111187

Jieping Sun , Huiyu Huang , Jinghan Dang , Mengzhe Zhang , Xiaoyu Niu , Qiuying Tao , Yimeng Kang , Longyao Ma , Bohui Mei , Weijian Wang , Shaoqiang Han , Jingliang Cheng , Yong Zhang

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引用次数: 0

摘要

背景：尼古丁成瘾（NA）被认为是一种影响个人和社会的重要神经行为障碍。有人认为，特定大脑网络内功能网络连接（FNC）的改变是其神经生物学基础：方法：利用 "人类连接组计划"（Human Connectome Project）的数据，确定默认模式网络（DMN）、执行控制网络（ECN）和显著性网络（SN）。研究对象包括47名NA患者和35名正常对照者（NC），他们都接受了静息态fMRI检查和与吸烟相关的临床评估。研究采用滑动窗口分析法评估连通性指标，包括静态功能网络连通性（FNC）、标准偏差（SD）和变异系数（CV），以比较两组之间的信息整合情况。根据六年来法格斯特伦尼古丁依赖测试（FTND）得分的纵向变化，将NA患者分为三类：成瘾倾向（AT）、戒断倾向（WT）和稳定倾向（ST）。进行相关性分析以探讨 FNC 异常与临床评估之间的关系：结果：NA患者的背侧DMN和右侧ECN之间的静态FNC减少（p_FDR = 0.029），同时SD（p_FDR = 0.029）和CV（p_FDR = 0.029）增加。在背侧 DMN 和左侧 ECN 中也观察到 SD（p_FDR = 0.049）的明显增加。相关性表明，背侧DMN和右侧ECN的SD与罗素吸烟原因问卷（RRSQ）量表的药理学维度相关（r = 0.416，p_FDR = 0.044），而CV与六年来FTND的变化相关（r = -0.391，p_FDR = 0.044），与RRSQ量表的药理学维度相关（r = 0.402，p_FDR = 0.044）。事后亚组分析显示，WT 患者中也存在这些 FNC 强度变化（p_FDR 结论）：DMN和ECN内大脑网络功能的改变被认为先于NA的行为改变。这些发现被解释为尼古丁成瘾的潜在神经生物学标记。

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Functional connectivity changes in males with nicotine addiction: A triple network model study

Background

Nicotine addiction (NA) is recognized as a significant neurobehavioral disorder that affects both individuals and society. It is suggested that alterations in functional network connectivity (FNC) within specific brain networks underlie its neurobiological basis.

Methods

The default mode network (DMN), executive control network (ECN), and salience network (SN) are identified using data from the Human Connectome Project. The study includes 47 individuals with NA and 35 normal controls (NC), all of whom undergo resting-state fMRI alongside smoking-related clinical assessments. A sliding window analysis is employed to assess connectivity metrics, including static functional network connectivity (FNC), standard deviation (SD), and coefficient of variation (CV), to compare information integration between the groups. Participants with NA are classified based on longitudinal changes in Fagerström Test for Nicotine Dependence (FTND) scores over six years into three categories: addiction tendency (AT), withdrawal tendency (WT), and stable tendency (ST). Correlation analyses are conducted to explore relationships between FNC abnormalities and clinical assessments.

Results

Individuals with NA exhibit reduced static FNC (p_FDR = 0.029) between the dorsal DMN and the right ECN, accompanied by increased SD (p_FDR = 0.029) and CV (p_FDR = 0.029). A significant increase in SD (p_FDR = 0.049) is also observed in the dorsal DMN and left ECN. Correlations indicate that the SD of the dorsal DMN and right ECN relates to the pharmacological dimension of the Russell Smoking Reasons Questionnaire (RRSQ) scale (r = 0.416, p_FDR = 0.044), while CV correlates with changes in the FTND over six years (r = −0.391, p_FDR = 0.044) and the pharmacological dimension of the RRSQ scale (r = 0.402, p_FDR = 0.044). Post-hoc subgroup analyses reveal that these FNC intensity changes are present among WT patients (p_FDR < 0.05).

Conclusions

Alterations in brain network function within the DMN and ECN are suggested to precede behavioral changes in NA. These findings are interpreted as potential neurobiological markers of nicotine addiction.

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来源期刊

Progress in Neuro-Psychopharmacology & Biological Psychiatry 医学-精神病学

CiteScore

12.00

自引率

1.80%

发文量

153

审稿时长

56 days

期刊介绍： Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.