在一组健康的足月儿童中评估青春期尿液中的性激素以及与人体测量学的相关性。

IF 5.4 2区 医学 Q1 Medicine
Viola Trevisani, Lucia Palandri, Beatrice Righi, Domenico Maione, Lisa De Pasquale, Enrico Tagliafico, Chiarina Grisolia, Mara Tagliazucchi, Barbara Predieri, Lorenzo Iughetti, Elena Righi, Laura Lucaccioni
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引用次数: 0

摘要

导言男孩和女孩的性早熟趋势不同。我们的研究旨在通过分析尿液中的性激素水平,探讨健康婴儿青春期发育的时间和动态。此外,我们还分析了HPG轴活动与线性生长、两性生殖器外侧距离(AGDs)和男性阴茎长度之间的关系:方法:对出生至 6 个月的健康足月儿进行纵向队列研究。分别在婴儿出生 0 个月(T0)、3 个月(T3)和 6 个月(T6)时进行临床评估(人体测量和 AGDs)和尿样采集。对尿液样本进行了促性腺激素和性激素分析:结果:共有 165 人参与。结果:165 名参与者的生长趋势和 AGD 都很正常。尿液中的激素彼此相关。具体而言,在男孩中,尿 FSH(uFSH)和尿 LH(uLH)之间的相关系数从 T0 到 T6 有所下降,而尿睾酮(uT)和尿 FSH 之间的相关系数则有所上升。在女孩中,uFSH 和尿雌二醇(uE)之间在每个时间点都存在相关性。值得注意的是,激素与人体测量学和 AGDs 之间存在一些相关性;最有趣的相关性出现在男性 uLH 和 PL 之间(T0 ρ:0.323, p 结论:尿基质已被证明是一种有价值的、实用的、非侵入性的、成本更低的性激素评估方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The assessment of urinary sexual hormones within minipuberty and correlations with anthropometrics in a cohort of healthy term children.

Introduction: Minipuberty follows different trends in boys and girls. Aim of our study was to explore timing and dynamics of minipuberty in healthy infants, analyzing urinary levels of sexual hormones. Moreover, we analyzed the association among HPG axis activity and linear growth, ano-genital distances (AGDs) in both sexes, and penile length in males.

Methods: Longitudinal cohort study in healthy term infants from birth to 6 months of life. Clinical evaluation (anthropometrics and AGDs) and urine sampling were performed at 0 (T0), 3 (T3), and 6 (T6) months. Urine samples were analyzed for gonadotropins and sex hormones.

Results: 165 participants were involved. The growth trend of our population was regular, as were the AGDs. Urinary hormones were correlated each other's. Specifically, in boys, the correlation coefficient between urinary FSH (uFSH) and urinary LH (uLH) decreased from T0 to T6, while between urinary Testosterone (uT) and uFSH increased. In girls, correlations between uFSH and urinary Estradiol (uE) were observed at each time point. Notably, several correlations between hormones and anthropometrics and AGDs were found; the most interesting correlation was found in males within uLH and PL (at T0 ρ: 0.323, p < 0.05 and at T3 ρ: 0.371, p < 0.01), whereas in females uFSH at T0 showed negative correlations with both length and body weight percentile at T3 (ρ: -0.505, p < 0.01 and ρ: -0.478, p < 0.01, respectively).

Conclusion: Urinary matrix has proved to be a valuable, practical, non-invasive and cheaper method for sexual hormone assessment.

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来源期刊
Journal of Endocrinological Investigation
Journal of Endocrinological Investigation ENDOCRINOLOGY & METABOLISM-
CiteScore
8.10
自引率
7.40%
发文量
242
期刊介绍: The Journal of Endocrinological Investigation is a well-established, e-only endocrine journal founded 36 years ago in 1978. It is the official journal of the Italian Society of Endocrinology (SIE), established in 1964. Other Italian societies in the endocrinology and metabolism field are affiliated to the journal: Italian Society of Andrology and Sexual Medicine, Italian Society of Obesity, Italian Society of Pediatric Endocrinology and Diabetology, Clinical Endocrinologists’ Association, Thyroid Association, Endocrine Surgical Units Association, Italian Society of Pharmacology.
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