实体器官移植受者的癌症死亡率：系统回顾和荟萃分析。

IF 4.3 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine Pub Date : 2024-11-02 DOI:10.1016/j.ypmed.2024.108161

Zhipeng Wang , Lihong Deng , Wen Hou , Shiyu Liu , Yacong Zhang , Chao Sheng , Yu Zhang , Jun Li , Zhongyang Shen

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引用次数: 0

摘要

目的：通过系统回顾和荟萃分析评估实体器官移植受者的癌症死亡风险：通过系统综述和荟萃分析评估实体器官移植受者的癌症死亡风险：在PubMed（始于1965年）、ISI Web of Science（始于1900年）、MEDLINE（始于1976年）和Scopus（始于1968年）数据库中进行系统检索，检索时间从各数据库建立之初至2024年7月15日。纳入的研究以英文发表，报告了任何类型实体器官移植受者中至少一种癌症的死亡风险。主要结果是移植受者与普通人群癌症死亡率的标准化死亡率（SMR），以及移植受者与未接受过移植的癌症患者癌症死亡率的危险比（HR）：与普通人群相比，实体器官移植受者的癌症死亡风险增加了 2.06 倍（SMR，2.06 [95 % CI，1.56-2.71]）。肾脏（SMR：1.92 [95 % CI：1.30-2.84]）、肝脏（SMR：3.07 [95 % CI：1.80-5.24]）和肺/心脏（SMR：4.87 [95 % CI：3.33-7.12]）移植受者的风险更高。曾接受移植手术的癌症患者的癌症死亡风险（HR 1.47 [95 % CI：1.29-1.68]）比未接受移植手术的患者高出 1.47 倍。东亚女性移植受者患乳腺癌、卵巢癌、宫颈癌和子宫癌的死亡风险高于其他地区（SMR 3.13 [95 % CI: 1.93-5.07] vs. 1.16 [95 % CI: 0.88-1.53], P 结论：东亚女性移植受者患乳腺癌、卵巢癌、宫颈癌和子宫癌的死亡风险高于其他地区：实体器官移植受者面临的癌症死亡风险明显高于普通人群，这凸显了进行有针对性的癌症筛查和干预的必要性，尤其是对东亚女性实体器官移植受者而言。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cancer mortality among solid organ transplant recipients: A systematic review and meta-analysis

Objectives

To evaluate the cancer mortality risk among solid organ transplant recipients through a systematic review and meta-analysis.

Methods

Systematic searches were conducted in PubMed (starting from 1965), ISI Web of Science (starting from 1900), MEDLINE (starting from 1976), and Scopus (starting from 1968) from the inception of each database until July 15, 2024. Studies published in English reporting at least one type of cancer mortality risk among recipients of any type of solid organ transplantation were included. The main outcomes were the standardized mortality ratio (SMR) for cancer mortality in transplant recipients compared to the general population, and the hazard ratio (HR) for cancer mortality in transplant recipients versus cancer patients without prior transplantation.

Results

Solid organ transplant recipients had a 2.06-fold increased cancer mortality risk (SMR, 2.06 [95 % CI, 1.56–2.71]) than the general population. Risks were higher in kidney (SMR 1.92 [95 % CI: 1.30–2.84]), liver (SMR 3.07 [95 % CI: 1.80–5.24]), and lung/heart (SMR 4.87 [95 % CI: 3.33–7.12]) transplant recipients. Cancer patients with prior transplantation had a 1.47-fold increased cancer mortality risk (HR 1.47 [95 % CI: 1.29–1.68]) than those without. East Asia female transplant recipients exhibited higher mortality risks from breast, ovarian, cervix and uterus cancers than those from other regions (SMR 3.13 [95 % CI: 1.93–5.07] vs. 1.16 [95 % CI: 0.88–1.53], P < 0.01).

Conclusions

Solid organ transplant recipients face significantly higher cancer mortality risks than the general population, highlighting the need for targeted cancer screening and interventions, especially for female solid organ transplant recipients from East Asia.

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来源期刊

Preventive medicine 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.70

自引率

3.90%

发文量

审稿时长

42 days

期刊介绍： Founded in 1972 by Ernst Wynder, Preventive Medicine is an international scholarly journal that provides prompt publication of original articles on the science and practice of disease prevention, health promotion, and public health policymaking. Preventive Medicine aims to reward innovation. It will favor insightful observational studies, thoughtful explorations of health data, unsuspected new angles for existing hypotheses, robust randomized controlled trials, and impartial systematic reviews. Preventive Medicine''s ultimate goal is to publish research that will have an impact on the work of practitioners of disease prevention and health promotion, as well as of related disciplines.