组蛋白去乙酰化酶家族在脂质代谢中的作用：结构特异性和功能多样性。

IF 9.1 2区医学 Q1 PHARMACOLOGY & PHARMACY

Pharmacological research Pub Date : 2024-11-02 DOI:10.1016/j.phrs.2024.107493

Yunxia Li , Qi Han , Yuxin Liu , Jie Yin , Jie Ma

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引用次数: 0

摘要

脂质在信号转导中起着至关重要的作用。脂质代谢与多种转录调节因子有关，包括过氧化物酶体增殖激活受体γ、固醇调节元件结合蛋白 1 和乙酰-CoA 羧化酶。近年来，越来越多的证据表明，组蛋白去乙酰化酶（HDAC）家族成员在脂质代谢中发挥着关键作用。然而，该家族各成员调节脂质代谢的机制仍不清楚。本综述将讨论有关 HDAC 在脂肪代谢中所起作用的最新研究。还讨论了 HDAC 在肥胖、糖尿病和动脉粥样硬化中的作用。此外，还综述了 HDACs 与肠道微生物组和昼夜节律的相互作用，并预测了 HDACs 的未来发展趋势，这可能会促进靶向 HDACs 在相关代谢疾病中的治疗应用。

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Role of the histone deacetylase family in lipid metabolism: Structural specificity and functional diversity

Lipids play crucial roles in signal transduction. Lipid metabolism is associated with several transcriptional regulators, including peroxisome proliferator activated receptor γ, sterol regulatory element-binding protein 1, and acetyl-CoA carboxylase. In recent years, increasing evidence has suggested that members of the histone deacetylase (HDAC) family play key roles in lipid metabolism. However, the mechanisms by which each member of this family regulates lipid metabolism remain unclear. This review discusses the latest research on the roles played by HDACs in fat metabolism. The role of HDACs in obesity, diabetes, and atherosclerosis has also been discussed. In addition, the interaction of HDACs with the gut microbiome and circadian rhythm has been reviewed, and the future development trend in HDACs has been predicted, which may potentiate therapeutic application of targeted HDACs in related metabolic diseases.

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来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.