具有主动体温调节功能的模块化人体模型,用于对流热疗设备的验证和检验。

IF 3 3区 医学 Q2 ONCOLOGY
International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-11-03 DOI:10.1080/02656736.2024.2421873
L Van den Bossche, W Vertessen, J Van den Bossche, O Rudenko, J Bogers, L Brancato
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引用次数: 0

摘要

目的:本研究旨在设计和制造一个用于热疗应用的模块化模型:本研究旨在设计和制造一种用于热疗应用的模块化模型,解决患者间热调节机制(如出汗率、代谢产热和血液再分布)的差异问题:该模型可通过连接相同的单元来构建不同重量和尺寸的模型。每个单元由琼脂块、乙基纤维素表层、热源、深层和表层水循环以及出汗机制组成。琼脂和乙基纤维素凝胶分别模拟人体组织和脂肪的热特性。实验块用 PVC 箔包裹,以防止水分蒸发。在嵌入的铝管上缠绕着加热丝,模拟新陈代谢产生的热量。表层水循环模拟皮肤毛细血管。水泵可确保整个管道系统保持稳定的流速。使用水泵和穿孔管模拟汗液产生。程序控制器可在正常操作模式下保持核心温度,并在麻醉模式下模拟麻醉病人:结果:在不同环境条件下对温度均匀性和调节进行了评估。在环境温度介于 21 °C 和 30 °C 之间时,模型有效地将核心温度控制在 37.0 °C +/- 0.7 °C。启动水循环后,模型内的最大温度梯度从 4.70°C 降至 1.92°C:多功能模型成功地模拟了热交换过程。它的热特性、尺寸和热交换率可以调整,以模拟不同的病人模型。这些结果很有希望成为热疗设备验证和检验的有效工具,代表人体的生理反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A modular, human body-mimicking phantom with active thermoregulation capabilities for validation and verification of convective hyperthermia devices.

Objectives: This study aims to design and fabricate a modular phantom for hyperthermia applications, addressing interpatient variability in thermal regulation mechanisms like sweating rate, metabolic heat production, and blood redistribution.

Materials & methods: The phantom can be constructed in various weights and dimensions by connecting identical units. Each unit consists of an agar-based block, an ethyl cellulose-based top layer, a heat source, deep and superficial water circulation, and a sweating mechanism. Agar and ethyl cellulose gels mimic the thermal properties of human tissues and fat respectively. The blocks are wrapped in PVC foil to prevent water evaporation. A heating wire, coiled around an embedded aluminum tubing simulates metabolic heat production. A superficial water circulation mimics skin capillaries. A water pump ensures a steady flow rate throughout the tubing system. Sweat production is simulated using a water pump and perforated tubing. A programmed controller maintains core temperature in a normal operating mode and simulates an anesthetized patient in anesthesia mode.

Results: Temperature uniformity and regulation were assessed under varying environmental conditions. The phantom effectively regulated its core temperature at 37.0 °C +/- 0.7 °C with an ambient temperature ranging between 21 °C and 30 °C. Activating the water circulation reduced the maximum temperature gradient within the phantom from 4.70 °C to 1.92 °C.

Conclusion: The versatile phantom successfully models heat exchange processes. Its thermal properties, dimensions, and heat exchange rates can be tuned to mimic different patient models. These are promising results as an effective tool for hyperthermia device validation and verification, representing human physiological responses.

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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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